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Clinical Trials/NCT07415603
NCT07415603
Not yet recruiting
Not Applicable

Variability and Correlation of the Pulse Pressure Variability (PPV) and the Plethysmography Variability Index (PVI) in the Supine and Prone Position

Joseph D. Tobias0 sites100 target enrollmentStarted: June 1, 2026Last updated:
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InterventionsObservation

Overview

Phase
Not Applicable
Status
Not yet recruiting
Sponsor
Joseph D. Tobias
Enrollment
100
Primary Endpoint
PPV Supine
OverviewStudy DesignEligibility CriteriaArms & InterventionsOutcomesInvestigatorsRecords & IdentifiersSimilar Trials

Overview

Brief Summary

This is a prospective study that will record the Pulse Pressure Variability (PPV) from the arterial line and Plethysmography Variability Index (PVI) from the pulse oximeter while the patient is in the supine position and then again in the prone position. There will be no change in anesthetic care based on the study protocol.

The primary objective of this study is to evaluate the changes in PVI and PPV when changing from the supine and prone position in pediatric-aged patients.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Consenting ASA 1-4 patients
  • •Undergoing a surgical procedure with general anesthesia that requires placement of an arterial cannula and prone positioning

Exclusion Criteria

  • •Patients in whom an arterial cannula is not indicated or cannot be placed
  • •Patients undergoing a surgical procedure that does not require prone positioning

Arms & Interventions

Prone surgical patients

Intervention: Observation (Other)

Outcomes

Primary Outcomes

PPV Supine

Time Frame: Once a minute for 5 minutes

Pulse Pressure Variability (PPV) recorded from the arterial line while supine.

PVI Supine

Time Frame: Once a minute for 5 minutes

Plethysmography Variability Index (PVI) recorded from the pulse oximeter while supine.

PPV Prone

Time Frame: Once a minute for 5 minutes

Pulse Pressure Variability (PPV) recorded from the arterial line while prone.

PVI Prone

Time Frame: Once a minute for 5 minutes

Plethysmography Variability Index (PVI) recorded from the pulse oximeter while prone.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Joseph D. Tobias
Sponsor Class
Other
Responsible Party
Sponsor Investigator
Principal Investigator

Joseph D. Tobias

Chief - Department of Anesthesiology & Pain Medicine

Nationwide Children's Hospital

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