Vitamin D Influence on Oocyte Donation

Completed

• Conditions: Disorder of Phosphate, Calcium and Vitamin D Metabolism; Female Infertility Due to Diminished Ovarian Reserve; Reproductive Disorder; Hormonal Requirement

• Registration Number: NCT02341365
• Lead Sponsor: IVI Madrid

Brief Summary

Objective: To investigate the correlation between total and bioavailable serum 25-OH vitamin D, ovarian reserve and ovarian response to controlled stimulation in egg donors.

Detailed Description

Design: Retrospective study. Setting: University affiliated private IVF center. Intervention: Serum analysis of vitamin D, bioavailable vitamin D, antimullerian hormone (AMH), antral follicular count (AFC), reproductive outcome of oocytes recipients Main outcome measure: AMH, AFC, number of oocytes retrieved and number of mature oocytes, pregnancy and implantation rate of donated oocytes'recipients.

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2014-11-07
• Primary Completion: 2014-12
• Status Verified: 2015-01
• Study Completion: 2015-01
• Study First Submitted QC: 2015-01-16
• Last Update Submitted: 2015-01-16
• Study First Posted: 2015-01-19
• Last Update Posted: 2015-01-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 269

Inclusion Criteria

• Caucasian race,
• between 18 and 34 years of age,
• all donors had normal menstrual cycles of 26-34 days,
• normal weight range (BMI 18- 25 Kg/m2),
• normal uterus and ovaries on transvaginal ultrasound (no signs of polycystic ovarian syndrome), and
• an antral follicle count (AFC) >10,
• normal karyotype

Exclusion Criteria

• current or past exposure to radiation or hazardous chemical substances,
• history of drug use,
• family history of hereditary chromosomal diseases,
• sexually transmitted diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Numbers of oocytes retrieved	2 months

Secondary Outcome Measures

Name	Time	Method
AMH	2 months
implantation rate	2 months
pregnancy rate	2 months
AFC	2 months
number of mature oocytes	2 months