Maximal Fat Oxidation During Exercise: Impact of Nutritional Status and Exhaustion
试验速览
- 阶段
- 不适用
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Maximal fat oxidation during exercise (MFO)
研究概览
简要总结
It is well known that, even in quite homogenous populations, inter-individual variability in fat oxidation during exercise, in particular MFO, is quite large. Individual factors like gender, body composition (lean mass) and fitness level do explain a substantial part of this variation. In addition, genetic factors do underlie differences between individuals. But also 'external factors' like nutritional status, i.e. a low or high carbohydrate (CHO) availability, and exhaustion are likely linked to maximal fat oxidation, due to alterations in substrate availability. The contribution of these external factors to alterations in substrate utilization is, as of yet, unknown.
This study aims to establish the impact of pre-exercise CHO availability and exhaustion on maximal fat oxidation (MFO & FATmax) during exercise
详细描述
Rationale: During exercise, energy expenditure increases dramatically, with exercise intensity as the single most important factor influencing substrate utilization. It is commonly reported that fat oxidation increases as exercise intensity increases, up to a certain point. At higher exercise intensities, fat oxidation declines quite rapidly, despite increased energy requirements, and carbohydrate becomes the predominant, and finally the only fuel source during (aerobic) exercise.
The maximal capacity of the human body to oxidize fat during exercise can quantitatively be described by the so-called 'MFO' and 'FATmax'. The MFO (maximal fat oxidation) is the highest absolute level of fat oxidation as expressed in gram per minute (g/min), while FATmax is the exercise intensity at which fat oxidation is highest (%VO2max or %HFmax). These concepts may have importance for endurance training and performance.
It is well known that, even in quite homogenous populations, inter-individual variability in fat oxidation, in particular MFO, is quite large. Individual factors like gender, body composition (lean mass) and fitness level do explain a substantial part of this variation. In addition, genetic factors do underlie differences between individuals. But also 'external factors' like nutritional status, i.e. a low or high carbohydrate (CHO) availability, and exhaustion are likely linked to maximal fat oxidation, due to alterations in substrate availability. The contribution of these external factors to alterations in substrate utilization is, as of yet, unknown.
Objective: The investigators aim to establish the impact of pre-exercise CHO availability and exhaustion on maximal fat oxidation (MFO & FATmax) during exercise.
Study design: The study consist of two parts. In part I the impact of carbohydrate availability will be assessed, in part II the impact of exhaustion.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Apparently healthy (self-reported)
- •aged between 20 and 35
- •BMI between 18.5 to 27 kg/m2
- •Recreationally active, defined as minimal of 3 hours training per week, and a maximum of 10 hours a week
- •The sport a participant is engaged in should be a game sport, endurance sport, or should at least contain a major endurance component. Examples of sports that can be included are: distance running, cycling, triathlon, crossfit, and game sports like soccer, rugby, handball, hockey,
- •○ For part 2 subjects should be used to prolonged cycling exercise
- •Able to be present and participate at all test days and willing and able to follow prescribed interventions
排除标准
- •Inactive (defined as <3 hours of training per week)
- •Non-recreational athlete (>10 hours of training per week)
- •active in a sport without a major endurance component
- •Smokers, defined as someone who has smoked regularly in the previous year.
- •Excessive alcohol consumption (i.e. more than 14 units for males per week; 7 units for females)
- •The more 'extreme' diets (like veganism, ketogenic diet, raw-food, carnivore diet etc.)
- •Participation in another biomedical study possibly interfering with the study results within 1 month before the first study visit
- •Inability to participate and/or complete the required measurements
- •People working for the department of Human Nutrition and Health (including Master thesis students)
结局指标
主要结局
Maximal fat oxidation during exercise (MFO)
时间窗: 36 hours
The main study parameter is maximal fat oxidation during exercise, expressed as MFO (g/min) as assessed during a graded exercise test (35W/ 3min protocol)
Relative intensity maximal fat oxidation during exercise ('Fatmax')
时间窗: 36 hours
The second study parameter is the relative exercise intensity at which maximal fat oxidation during exercise occurs, expressed as nd FATmax (%) as assessed during a graded exercise test (35W/ 3min protocol)
次要结局
未报告次要终点