The Effect of Esophageal Doppler Guided Goal-directed Hemodynamic Therapy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Lactate
研究概览
简要总结
Prospective randomized clinical trial Compare the goal-directed fluid therapy using esophageal Doppler and classic fluid therapy
详细描述
Goal directed fluid therapy becomes issue for enhanced recovery after surgery. In goal directed therapy, dynamic parameters, like stroke volume and cardiac output, is important. Esophageal Doppler is one of device which provides dymanic parameters.
In severe trauma cases, the effect of goal directed therapy is not known yet. So the aim of this study is comparing the results of goal directed therapy using esophageal Doppler and conventional fluid therapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Severe trauma patients who undergo general anesthesia
- •Initial serum lactate level > 2mmol/L
排除标准
- •Severe traumatic brain injury
- •THoracic surgery
- •Age < 19 years old
- •Impending arrest or post CPR state
- •Severe facial trauma
结局指标
主要结局
Lactate
时间窗: Immediate postoperative (=initial ICU admission)
Unit is mmol/L Inclusion criteria is initial lactate \> 2mmol/L. Whole hospital use same device and unit to measure lactate. In this study, POCT lactate won't be used. After surgical resuscitation, lactate level is independent predictor of survival, because it represents tissue oxygenation.
次要结局
- Creatinine(Immediate postop)
- Acute Physiology and Chronic Health Evaluation II (APACHE II) score(Immediate postoperative)
研究者
In-kyong Yi
Clinical assistant professor
Ajou University School of Medicine