The Effect of Esophageal Doppler Guided Goal-directed Hemodynamic Therapy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Trauma
- Sponsor
- Ajou University School of Medicine
- Enrollment
- 46
- Locations
- 1
- Primary Endpoint
- Lactate
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Prospective randomized clinical trial Compare the goal-directed fluid therapy using esophageal Doppler and classic fluid therapy
Detailed Description
Goal directed fluid therapy becomes issue for enhanced recovery after surgery. In goal directed therapy, dynamic parameters, like stroke volume and cardiac output, is important. Esophageal Doppler is one of device which provides dymanic parameters. In severe trauma cases, the effect of goal directed therapy is not known yet. So the aim of this study is comparing the results of goal directed therapy using esophageal Doppler and conventional fluid therapy.
Investigators
In-kyong Yi
Clinical assistant professor
Ajou University School of Medicine
Eligibility Criteria
Inclusion Criteria
- •Severe trauma patients who undergo general anesthesia
- •Initial serum lactate level \> 2mmol/L
Exclusion Criteria
- •Severe traumatic brain injury
- •THoracic surgery
- •Age \< 19 years old
- •Impending arrest or post CPR state
- •Severe facial trauma
Outcomes
Primary Outcomes
Lactate
Time Frame: Immediate postoperative (=initial ICU admission)
Unit is mmol/L Inclusion criteria is initial lactate \> 2mmol/L. Whole hospital use same device and unit to measure lactate. In this study, POCT lactate won't be used. After surgical resuscitation, lactate level is independent predictor of survival, because it represents tissue oxygenation.
Secondary Outcomes
- Creatinine(Immediate postop)
- Acute Physiology and Chronic Health Evaluation II (APACHE II) score(Immediate postoperative)