Epileptogenic Zone's Cartography by Quantification of EEG's Signal and Intracerebral Stimulation.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Epilepsy
- Sponsor
- University Hospital, Grenoble
- Enrollment
- 45
- Locations
- 1
- Primary Endpoint
- Connectivity maps
- Last Updated
- 9 years ago
Overview
Brief Summary
Epilepsy is a devastating chronic disease due to multiple causes that affect close to 50% of the world's population.
Although effective, epilepsy surgery fails in many cases, the percentage of patients free from crisis on a long term (≥ 5 years) varies from 27% to 66% according to the kind of epilepsy.
It is in this context that EPISTIM is interesting, and its aims isb a better electrophysiology delimiting of cortical networks that imply the genesis of seizures with the aim to improove surgery results.
This study will rely on the intracerebral records and on corticales electrical stimulation as they are currently routinely used by epileptic patients candidates for surgery.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Connectivity maps
Time Frame: up to 10 min
Connectivity maps : calculated for each site stimulated at low-frequency.
Visual analysis
Time Frame: up to one hour
Visual analysis : in order to define the level of cortical resections.
Epileptogenic maps
Time Frame: up to 10 min
Epileptogenic maps : calculated for each crisis and for all crisis in general.
MRI
Time Frame: up to one hour
Post-operative evaluation : in order to assess the extent of resection. MRI : 3D-T1