Epileptogenic Zone's Cartography by Quantification of EEG's Signal and Intracerebral Stimulation.

Not Applicable

• Conditions: Epilepsy

• Registration Number: NCT02844374
• Lead Sponsor: University Hospital, Grenoble

Brief Summary

Epilepsy is a devastating chronic disease due to multiple causes that affect close to 50% of the world's population.

Although effective, epilepsy surgery fails in many cases, the percentage of patients free from crisis on a long term (≥ 5 years) varies from 27% to 66% according to the kind of epilepsy.

It is in this context that EPISTIM is interesting, and its aims isb a better electrophysiology delimiting of cortical networks that imply the genesis of seizures with the aim to improove surgery results.

This study will rely on the intracerebral records and on corticales electrical stimulation as they are currently routinely used by epileptic patients candidates for surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Status Verified: 2016-07
• Study First Submitted: 2016-07-18
• Study First Submitted QC: 2016-07-25
• Last Update Submitted: 2016-07-25
• Study First Posted: 2016-07-26
• Last Update Posted: 2016-07-26
• Primary Completion: 2017-01
• Study Completion: 2017-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Connectivity maps	up to 10 min	Connectivity maps : calculated for each site stimulated at low-frequency.
Visual analysis	up to one hour	Visual analysis : in order to define the level of cortical resections.
Epileptogenic maps	up to 10 min	Epileptogenic maps : calculated for each crisis and for all crisis in general.
MRI	up to one hour	Post-operative evaluation : in order to assess the extent of resection. MRI : 3D-T1

Trial Locations

Locations (1)

UniversityHospitalGrenoble; 🇫🇷 La Tronche, France