The Role of IEEG in the Localization of EZ and Its Relationship With Prognosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Epilepsy
- Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Comparison of clinical data and IEEG characteristics in the seizure-free and not seizure-free groups
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The mechanism of epilepsy pathogenesis is complex and not fully defined, and about 20-30% of patients with seizures that cannot be completely controlled by drugs become drug-resistant epilepsy. For focal drug-resistant epilepsy, surgical removal of the epileptogenic zone can control seizures, but the overall seizure-free rate in the long term after surgery is 60-70%, and the results are still not satisfactory. Accurate assessment of the location and extent of the epileptogenic zone and its adequate excision are prerequisites for the success or failure of surgery. Intracranial EEG (iEEG) has been shown to be the most accurate method for determining the location and boundaries of the epileptogenic zone. It can selectively record the local cortical electrical activity through intracranial electrodes and achieve high temporal resolution for long-range recording, reliably reflecting the continuous dynamic changes of EEG during interictal and ictal periods. The in-depth analysis of iEEG can improve the efficacy of epilepsy surgery and provide important information to reveal the pathogenesis of epilepsy.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Complete clinical history;
- •IEEG monitoring at least one habitual seizure；
- •Follow up for at least 1 year；
- •Signed informed consent.
Exclusion Criteria
- •Habitual seizures were not found in iEEG monitoring;
- •No operation was performed;
- •Lost to follow-up for various reasons within 1 year after surgery.
Outcomes
Primary Outcomes
Comparison of clinical data and IEEG characteristics in the seizure-free and not seizure-free groups
Time Frame: 1-2 years
Compare two groups of patients with clinical data (sex, age at onset, age at surgery, epilepsy duration, seizure lateralization/localization, MRI findings, Pathology) and EEG characteristics (contact number, EEG onset pattern, IEEG power of each frequency band, functional connectivity of each frequency band).