The Long Term Clinical Course of Postinfectious Irritable Bowel Syndrome After Shigellosis; A 10 Year Follow up Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 229
- 主要终点
- Questionnaire survey for bowel symptoms
研究概览
简要总结
Background: The incidence of postinfectious irritable bowel syndrome (PI-IBS) was reported to be in the range of 5-30%, but limited number of long-term follow-up results.
Objective: To investigate the long term clinical course of PI-IBS after Shigellosis.
Setting: A Shigellosis outbreak in a tertiary referral hospital with about 2,000 employees in Korea at 2001.
Patients: A Shigella-exposed cohort of 124 hospital employees who had been infected by Shigella sonnei due to contaminated food in the employee-cafeteria in Gangnam Severance Hospital, Seoul, Korea, at December 2001. A control cohort of age and sex-matched, non-infected 105 contemporary hospital employees.
Measurements: Questionnaire survey for bowel symptoms at 1, 3, 5, 8 and 10 years after outbreak.
详细描述
Postinfectious-IBS (PI-IBS) can be defined as the acute onset of new IBS symptoms in an individual, who has not previously met the criteria for IBS, immediately following an acute illness characterized by 2 or more of the following: fever, vomiting, diarrhea, or a positive bacterial stool culture.
Our group previously have reported clinical course of PI-IBS in a homogenous cohort which was comprised of patients recovered from Shigellosis. And in current study, we finally report a collective result of 10-year long-term follow-up of our small, but well-followed, homogenous cohort of PI-IBS after Shigellosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Shigella sonnei infected patients
排除标准
- •refused to participate in these surveys
- •pregnant or had history of abdominal surgery or chronic organic gastrointestinal disorder
结局指标
主要结局
Questionnaire survey for bowel symptoms
时间窗: up to 10 years after outbreak
次要结局
未报告次要终点