Lactate Levels Correlates With Ki-67 in Brain Tumor Surgery

Completed

• Conditions: Anesthesia; Brain Tumor
• Interventions: Other: Data correlation

• Registration Number: NCT03531307
• Lead Sponsor: Ricard Valero

Brief Summary

In neurosurgery, brain tumor patients show increased levels of lactate at the beginning of surgery. This has been related to malignancy. Ki-67 is a cell proliferation index used as a marker of tumor mitotic activity.

This research aims to describe the correlation between lactate levels and the Ki-67 index in patients with brain tumor.

Detailed Description

Lactate levels are used in the evaluation of perfusion status in critical care. Increases not related to a hypoperfusion state are observed in the patient with brain tumors. These increases have been related to type and tumor grade. This observation does not fully explain the variation within the same tumor grade.

Ki-67 label index is a marker of mitotic activity that can be used as proliferation index. It has been associated with histologic grade and survival rate. Provides a quantitative measure of the tumor proliferation status.

The investigators will perform a retrospective analysis of the clinical charts of patients after brain tumor resection. The study will address the relationship between baseline lactate levels and the proliferation index found in tissues biopsies.

Study Timeline

• Study First Submitted: 2018-04-24
• Study First Submitted QC: 2018-05-09
• Study First Posted: 2018-05-21
• Study Start: 2018-05-30
• Primary Completion: 2018-07-30
• Study Completion: 2018-08-02
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-13
• Last Update Posted: 2019-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Neurosurgical craniectomy cases
• June 2017 - February 2018
• Valid lactate information after anesthesia induction
• Ki-67 label index informed in biopsies
• Tumor type information confirmed in biopsies

Exclusion Criteria

• Incomplete lactate or Ki-67 index information

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Lactate and Ki 67 levels	Data correlation	Neurosurgical patients between June 2017 and February 2018 for tumoral and non-tumoral craniectomy with lactate levels at the beginning of surgery and Ki-67 index in biopsies.

Primary Outcome Measures

Name	Time	Method
Evaluate the correlation between Lactate levels and Ki-67 Index	Within 1 week after data acquisition	Levels of lactate in first blood analysis after anesthesia induction and proliferation index in biopsy results

Trial Locations

Locations (1)

Anesthesia department, Hospital Clínic de Barcelona; 🇪🇸 Barcelona, Spain