Perioperative Lactate Kinetics in Patient Undergoing Major Liver Surgery
Completed
- Conditions
- Liver Failure, Acute
- Interventions
- Diagnostic Test: serum lactate
- Registration Number
- NCT04512014
- Lead Sponsor
- Institutul Clinic Fundeni
- Brief Summary
Major liver surgery is associated with increased incidence of perioperative complications and increased mortality if these are not addressed quickly in a high dependency intensive care unit. Of these, posthepatectomy liver failure (PHLF) represents one of the most important cause of postoperative unfavourable outcome. The present study investigates the correlation between lactate levels and PHLF. Lactate levels were collected at six specific timepoints: preoperative, pre-dissection phase, post-dissection phase, end of surgery and 24-hours and 48-hours in the postoperative period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 55
Inclusion Criteria
- patients undergoing major liver surgery for primary or secondary tumours
Exclusion Criteria
- unsigned patient consent
- death within 24 hours
- need for perioperative renal replacement therapy
- underlying liver disease (e.g. liver cirrhosis)
- other causes of raised lactate levels (e.g. shock)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description major liver surgery serum lactate Patients undergoing major liver surgery
- Primary Outcome Measures
Name Time Method lactate levels (mmol/L) in patients with PHLF early postoperative period (48 hours) correlation of lactate levels with the diagnosis of PHLF
- Secondary Outcome Measures
Name Time Method mortality 30 days mortality in hospital mortality
Trial Locations
- Locations (1)
Fundeni Clinical Institute
🇷🇴Bucharest, Romania