Risk Factors for Major Complications After Liver Resection

Completed

• Conditions: Liver Diseases

• Registration Number: NCT03967067
• Lead Sponsor: Moroccan Society of Surgery

Brief Summary

The aim of this study is to determine the risk factors for major complications following liver resection in the setting of a general surgery-teaching department in Morocco, North Africa

Detailed Description

Over the past 20 years, the refinement of liver surgery techniques, anesthesiology and perioperative management has dramatically improved the safety of liver resection patients. It has also led to a concomitant extension of indications for a growing number of patients with complex benign or malignant hepatobiliary diseases and/or high risk surgeries.

Published complication rates and risk prediction models and recommendations for patients undergoing liver resection primarily stem from far East or Western high-volume specialized centers. In developing countries, including those in North Africa, specific constraints (e.g., endemic indications, such as liver cystic hydatidosis, blood shortage, and the scarcity of liver surgeons and intensive care providers) may impact liver resection outcomes but they are rarely addressed in the literature.

The aim of this study was to determine the risk factors for major complications following liver resection in the setting of a general surgery-teaching department in Morocco, North Africa

Study Timeline

• Study Start: 2010-01-01
• Primary Completion: 2016-03-31
• Study Completion: 2016-12-31
• Status Verified: 2019-05
• Study First Submitted: 2019-05-26
• Study First Submitted QC: 2019-05-26
• Last Update Submitted: 2019-05-26
• Study First Posted: 2019-05-30
• Last Update Posted: 2019-05-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 213

Inclusion Criteria

• all patients who underwent an hepatectomy
• between january 2010 and December 2015

Exclusion Criteria

• All patient who only underwent liver biopsy with no resection
• Patients non operated

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
90-day Mortality rate	90 days from surgery	Death within 90 days of surgical procedure
90-day Complication rate	90 days from surgery	Defined by Clavien-Dindo grade I to IV within90 days of surgical procedure

Secondary Outcome Measures

Name	Time	Method
Risk factor of major complication at 90-day	90 days from surgery	defined by multivariate logistic regression of 90 day complication with Clavien-Dindo more than grade III

Trial Locations

Locations (1)

Ibn Sina Hospital, Surgical department A; 🇲🇦 Rabat, Morocco