Prognostic Relevance of Biological Subtype Overrides That of TNM Staging in Breast Cancer: Discordance Between Stage and Biology
试验速览
- 阶段
- 不适用
- 入组人数
- 202
- 试验地点
- 1
- 主要终点
- Overall survival
研究概览
简要总结
Recently, the investigators face "on the edges" for treatment decision to decide adjuvant systemic treatment, especially for patients who show discordance between stage and tumor biology. The aim of this study was to compare the prognostic relevance of the TNM staging system and intrinsic subtype in breast cancer patients who received curative surgery.
详细描述
Identified patients who received curative surgery for stage I-III breast cancer and had available data on immunohistochemistry profiles including hormone receptor status (HR) status, human epidermal growth factor receptor 2 (HER2) status, and Ki 67 staining at Samsung Medical Center from January 2004 to September 2008. Primary outcomes were recurrence-free survival (RFS) and overall survival (OS).
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patients who received curative surgery
- •stage I-III breast cancer
- •between January 2004 and September 2008
- •had available immunohistochemistry profiles.
- •exclusion Criteria:
- •age <18 years old
- •microinvasive carcinoma of breast
排除标准
- 未提供
结局指标
主要结局
Overall survival
时间窗: 1 year
was measured from the first date of diagnosis of breast cancer to the date of death or the last follow-up visit
次要结局
- Recurrence-free survival(1 Year)
研究者
Young-Hyuck Im
Professor
Samsung Medical Center