Residual effects of Cushing*s syndrome after long term remission: Impact on adipose tissue, insulin resistance, exercise intolerance and increased risk of cardiovascular disease.

Completed

Conditions: Hypercortisolism
10052547
10028393
10047066

Registration Number: NL-OMON37749

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

- Subjects should be over 18 years old with the ability to read and comprehend the Dutch language
- Patients should be successfully cured for at least five years. Current remission should be confirmed by a recent 1mg dexamethasone suppression test

Exclusion Criteria

- GH deficiency (This should be ruled out by an insulin tolerance test or an arginine/GHRH test) unless GH is properly supplemented (IGF-1 * 2)
- Serious co-morbidity (i.e. terminal malignancy, serious psychiatric pathology)
- Pregnancy
- Known diabetes mellitus
- Use of medication interfering with the cardiovascular system (ACE inhibitors, calcium antagonists, angiotensin II receptor antagonists) or adiponectins (thiazolidinediones)
- Severe cardiopulmonary disease as stated in the 2001 American heart association and 2002 American college of cardiology/American heart association guidelines
- Orthopedic and/or neurological diseases that impair exercise

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- Physical fitness measured with an incremental cycling exercise test to<br /><br>exhaustion (VO2max-test).<br /><br>- Brachial %FMD levels as a marker of conduit artery endothelial function,<br /><br>NO-mediated endothelium-(in)dependent vasodilation of the forearm resistance<br /><br>arteries.<br /><br>- Mitochondrial and capillary density, eNOS levels and eNOS phosphorylation,<br /><br>NADPH oxidase activation, total JNK activity levels and expression of IKK* in<br /><br>skeletal muscle cells.<br /><br>- Amount of cytokines, adipokines and their mRNA and macrophage infiltration in<br /><br>subcutaneous fat tissue.</p><br>

Secondary Outcome Measures