Erector Spinae Versus Intercostal Nerve Blocks With Liposomal Bupivacaine for Analgesia in Thoracic Surgery

Phase 3

Recruiting

• Conditions: Lung Cancers
• Interventions: Drug: Erector Spinae (ESP) Block with Bupivacaine (Marcaine®); Drug: Intercostal nerve block

• Registration Number: NCT06810375
• Lead Sponsor: George Washington University

Brief Summary

This clinical trial compares efficacy in postoperative pain management in thoracic surgery between erector spinae block versus liposomal bupivacaine injections.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2025-01-24
• Study First Submitted QC: 2025-01-31
• Status Verified: 2025-02
• Study First Posted: 2025-02-05
• Study Start: 2025-03-01
• Last Update Submitted: 2025-04-16
• Last Update Posted: 2025-04-20
• Primary Completion: 2028-02-28
• Study Completion: 2029-02-28

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Video assisted pulmonary resection, pleurodesis or decortication

Exclusion Criteria

• Allergy to local anesthetics
• Patient undergoing bilateral surgery
• Surgery is emergent as deemed by the principal investigator

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Preoperative Erector Spinae Block (ESB)(Bupivacaine)(Marcaine®)	Intercostal nerve block	-
Intraoperative Intercostal Nerve Block (INB)(Liposomal Bupivacaine)(Exparel®)	Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)	-
Intraoperative Intercostal Nerve Block (INB)(Liposomal Bupivacaine)(Exparel®)	Intercostal nerve block	-
Preoperative Erector Spinae Block (ESB)(Bupivacaine)(Marcaine®)	Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)	-

Primary Outcome Measures

Name	Time	Method
Postoperative pain control assessment	Up to 48 hours postoperatively	Study team will assess postoperative pain scores at 6, 12, 24 and 48 hours (Minimum numerical pain score of 0 and a maximum of 10)
Morphine equivalent assessment	Up to 72 hours postoperatively	Study team will collect information on all administered pain medications to calculate morphine equivalents

Secondary Outcome Measures

Name	Time	Method
Postoperative pain control assessment	Up to 72 hours postoperatively	Study team will assess postoperative pain scores at 72 hours (Minimum numerical pain score of 0 and a maximum of 10)

Trial Locations

Locations (1)

The George Washington University Hospital; 🇺🇸 Washington, District of Columbia, United States