Effects of Home-based Exercise in Advanced Chronic Kidney Disease and End-stage Renal Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Kidney Disease
- Sponsor
- Cardenal Herrera University
- Enrollment
- 57
- Locations
- 1
- Primary Endpoint
- Change from baseline sit to stand 10 test at 12 and 24 weeks
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
A home-based exercise program will be implemented in three different groups of participants: advanced chronic kidney disease, end-stage renal disease in substitutive treatment hemodialysis or peritoneal dialysis. Participants will be evaluated before the program, after 3 months and after 6 months from the starting of the program. During the first 3 months the researcher will phone them weekly to reinforce the exercise habit, and during the last three months, there will be no reinforcement. Assessment will include strength, functional capacity, health-related quality of life and depressive symptoms.
Detailed Description
Three groups of participants (advanced chronic disease not yet in substitutive treatment, end-stage renal disease patients in hemodialysis and end-stage renal disease patients in peritoneal dialysis) will enter the study. The intervention will consist of a home-based exercise program. They will be provided with a booklet and the researcher will explain personally each of the exercises to the participants. Progression will be encouraged so that the participants should find the sessions 'somewhat hard' according to the rate of perceived exertion. Reinforcement will be high during the first 3 months (weekly phone calls, visits to the nephrology department) and none during the last 3 months. Assessment will be undertaken at three-time points: baseline, after 3 months of high reinforcement and after 3 more months of no reinforcement at all. Assessment will include strength, functional capacity, health-related quality of life, cognitive state and depressive symptoms. The aim of the study is to assess the effectiveness of home-based exercise to improve strength, physical function, health-related quality of life, cognitive state and depressive symptoms in advanced chronic kidney disease and end-stage renal disease (hemodialysis and peritoneal dialysis). We also aim at describing all these variables in the three different groups of patients. Adherence and satisfaction with the exercise program will be recorded at the end of the study. Additionally, interobserver reliability will be calculated, so as reliability intraobserver in different measurement conditions (dialysis vs non-dialysis days).
Investigators
Eva Segura Ortí
Professor
Cardenal Herrera University
Eligibility Criteria
Inclusion Criteria
- •At least 3 months in hemodialysis treatment
- •Clinically stable
Exclusion Criteria
- •Recent cardiac events (less than 3 months)
- •Unable to exercise
Outcomes
Primary Outcomes
Change from baseline sit to stand 10 test at 12 and 24 weeks
Time Frame: Baseline,1 week, non-dialysis day baseline,12 weeks, 24 weeks
Sit to stand to sit test 10, time to perform 10 repetitions
Secondary Outcomes
- Change from baseline Handgrip strength (dynamometry) at 12 and 24 weeks(Baseline,1 week, non-dialysis day baseline,12 weeks, 24 weeks)
- Change from baseline Six-minute walking test at 12 and 24 weeks(Baseline,1 week, non-dialysis day baseline,12 weeks, 24 weeks)
- Change from baseline OLHR at 12 and 24 weeks(Baseline,1 week, non-dialysis day baseline,12 weeks, 24 weeks)
- Change from baseline STS-60 at 12 and 24 weeks(Baseline,1 week, non-dialysis day baseline,12 weeks, 24 weeks)
- Change from baseline SPPB at 12 and 24 weeks(Baseline,1 week, non-dialysis day baseline,12 weeks, 24 weeks)
- Change from baseline TUG at 12 and 24 weeks(Baseline,1 week, non-dialysis day baseline,12 weeks, 24 weeks)
- Change from baseline Health-related quality of life measured through the Euro quality of life questionnaire, 5 dimensions, at 12 and 24 weeks(Baseline,12 weeks, 24 weeks)
- Change from baseline Beck depression inventory at 12 and 24 weeks(Baseline,12 weeks, 24 weeks)
- Change from baseline OLST at 12 and 24 weeks(Baseline,1 week, non-dialysis day baseline,12 weeks, 24 weeks)
- Change from baseline Physical Activity Scale for the elderly at 12 and 24 weeks(Baseline,12 weeks, 24 weeks)
- Change from baseline Albumin at 12 and 24 weeks(Baseline,12 weeks, 24 weeks)
- Change from baseline Human activity profile at 12 and 24 weeks Human activity profile(Baseline,12 weeks, 24 weeks)
- Adherence(12 weeks, 24 weeks)