Clinical Profile of Acute on Chronic Liver Failure and Chronic Liver Failure Consortium Acute on Chronic Liver Failure (CLIF C ACLF) score as a predictor of its short-term mortality

NEED FOR THE STUDY

It is very important to stratify patients according to prognosis, monitor treatment responsiveness, determine emergency for transplantation, decide allocation in the intensive care unit (ICU), and have a rational basis to decide futility. Despite this catastrophic presentation and outcome, there is a component of potential reversibility with adequate support and management of the precipitating factor. Although several lines of evidence demonstrate that CLIF C ACLF prognostic score is superior to the conventional prognostic scores for the estimation of prognosis in these patients, the optimum score with the highest performance has not been enough explored yet, especially in India. A universally accepted prognostic model for ACLF is lacking due to discrepancies and unevenness in the definition of ACLF.

DESCRIPTION

Patients will be selected based on the above criteria and recruited into the study after taking informed written consent, confidentiality will be maintained. Demographic and clinical data of every patient with ACLF including age, gender, and BMI will be recorded in a data Proforma. Laboratory data including complete blood count, renal function and liver function tests, coagulation profile, and arterial blood gas analysis done at 48 hours of admission will be documented. CLIF C ACLF score will be calculated and patients will be categorized into various grades of CLIF C ACLF. Clinical outcomes will be assessed by: 1) 28-day mortality, 2) in-hospital mortality, and 3) duration of ICU/ HDU stay among various grades of CLIF C AClF. As this study is purely observational, patient management and antimicrobial therapy will be chosen by patients’ physicians without any intervention from study investigators.