Clinical Profile of Acute on Chronic Liver Failure and Chronic Liver Failure Consortium Acute on Chronic Liver Failure (CLIF C ACLF) score as a predictor of its short-term mortality
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Amar Minda
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- To look for 28 day mortality, in hospital mortality and duration of ICU stay among various grades of CLIF C-ACLF
Overview
Brief Summary
NEED FOR THE STUDY
It is very important to stratify patients according to prognosis, monitor treatment responsiveness, determine emergency for transplantation, decide allocation in the intensive care unit (ICU), and have a rational basis to decide futility. Despite this catastrophic presentation and outcome, there is a component of potential reversibility with adequate support and management of the precipitating factor. Although several lines of evidence demonstrate that CLIF C ACLF prognostic score is superior to the conventional prognostic scores for the estimation of prognosis in these patients, the optimum score with the highest performance has not been enough explored yet, especially in India. A universally accepted prognostic model for ACLF is lacking due to discrepancies and unevenness in the definition of ACLF.
DESCRIPTION
Patients will be selected based on the above criteria and recruited into the study after taking informed written consent, confidentiality will be maintained. Demographic and clinical data of every patient with ACLF including age, gender, and BMI will be recorded in a data Proforma. Laboratory data including complete blood count, renal function and liver function tests, coagulation profile, and arterial blood gas analysis done at 48 hours of admission will be documented. CLIF C ACLF score will be calculated and patients will be categorized into various grades of CLIF C ACLF. Clinical outcomes will be assessed by: 1) 28-day mortality, 2) in-hospital mortality, and 3) duration of ICU/ HDU stay among various grades of CLIF C AClF. As this study is purely observational, patient management and antimicrobial therapy will be chosen by patients’ physicians without any intervention from study investigators.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18.00 Year(s) to 99.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients of both genders aged more than 18 years with the diagnosis of ACLF according to the EASL CLIF definition.
Exclusion Criteria
- •Previously diagnosed Hepatocellular carcinoma
- •Have severe chronic extrahepatic disease
- •Retro positive
- •Patient on immunosuppressive drugs
- •Acute CVA
- •Orthotopic liver transplantation during follow- up
- •Pregnant females
- •Those who are not willing to participate in the study.
Outcomes
Primary Outcomes
To look for 28 day mortality, in hospital mortality and duration of ICU stay among various grades of CLIF C-ACLF
Time Frame: at 48 hours and 28 days
Secondary Outcomes
- not applicable(not applicable)
Investigators
Amar Minda
Kasturba Medical College Manipal