D Vitamin and Alveolar Macrophages in Idiopathic Pulmonal Fibrosis

Recruiting

• Conditions: Idiopathic Pulmonary Fibrosis (IPF)

• Registration Number: NCT06909409
• Lead Sponsor: University of Aarhus

Brief Summary

The goal of this observational study is to gain deeper insights into human macrophages and vitamin D, and their interplay, within Idiopathic Pulmonary Fibrosis (IPF).

The overall questions, it aims to answer, are the following:

Do IPF patients suffer from systemic and local (pulmonary) insufficient levels of vitamin D? Do IPF patients suffer from pro-fibrotic and pro-inflammatory pulmonary macrophages?

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-10
• Study Start: 2024-10-11
• Study First Submitted: 2025-03-27
• Study First Submitted QC: 2025-03-27
• Last Update Submitted: 2025-03-27
• Study First Posted: 2025-04-03
• Last Update Posted: 2025-04-03
• Primary Completion: 2026-10-11
• Study Completion: 2026-10-11

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• A clinical diagnosis of IPF, non-IPF ILD or lung cancer
• A signed informed consent

Exclusion Criteria

• Do not speak Danish/Do not understand Danish

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vitamin D status	At enrollment	Significant change in vitamin D levels in systemic (blood) and local (pulmonary) metabolism.
Pulmonary macrophages	At enrollment	Significant change in alveolar macrophage phenotype

Secondary Outcome Measures

Name	Time	Method
Biomarker levels in blood and BAL samples	At enrollment	Significant change in levels of macrophage and inflammatory/fibrotic biomarkers

Trial Locations

Locations (1)

Aarhus University Hospital, Denmark; 🇩🇰 Aarhus N, Denmark