Chest ultrasonographic evaluation after intrapleural Alteplase versus Streptokinase injection in Children with Empyema

Phase 3

• Conditions: Respiratory; Paediatrics

• Registration Number: PACTR202306656398595
• Lead Sponsor: Assiut University Children Hospital.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-03-07
• Last Update Posted: 4 March 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

Age: from1 month to18 years.
Gender: both sexes will be included in the study.
Empyema or CPPE along with evidence of septated pleural effusion on chest ultrasonography.
All patients will undergo chest tube insertion along with intravenous antibiotics.

Exclusion Criteria

Age below 1 month.
Patients with chronic empyema which is characterized by thickened visceral and parietal peels which hamper the ability of affected lung to re-expand and required definitive surgical intervention.
Patients with bleeding tendency, recent trauma, recent operation and on anticoagulation.
Children with pleural empyema from tuberculosis or malignancy.
Children with allergy to tPA or streptokinase.
Children with minimal parapneumonic effusion that do not require chest tube insertion.
Presence of bronchopleural fistula or pyopneumothorax.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome is assessment of the benefit and possible complications of intrapleural injection of tissue plasminogen activator and streptokinase in children with CPPE or empyema.<br><br>

Secondary Outcome Measures

Name	Time	Method
To compare between intrapleural injection of tissue plasminogen activator versus streptokinase in children with CPPE or empyema in reducing the need of further surgical intervention.<br>