The Effect of Oral Midodrine Versus Oral Desmopressin Acetate Use for Liberation From IV Noradrenaline in Intensive Care Unit Patients Recovering From Spinal Shock .
试验速览
- 阶段
- 2 期
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- liberation the patient from IV vasopressors with maintaining hemodynamics.
研究概览
简要总结
the study is developed to evaluate the effect of use of oral vasopressors (midodrine versus minirin) on weaning ICU patients from IV vasopressors (noradrenaline) and compare between them for efficacy in shortage the duration of IV vasopressor and has low complications and side effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age of 18 - 60 years.
- •Patients of both genders.
- •Patients diagnosed by spinal shock and they are in the recovery stage .
排除标准
- •Patient refusal.
- •Anuric or oliguric patients or patients with chronic kidney disease.
- •Patients with allergy to medication included in the study.
研究组 & 干预措施
midodrine group
midodrine group will receive midodrine 10 mg PO q8hr with gradual weaning of IV noradrenaline after receiving 4 doses of oral midodrine
干预措施: Midodrine Oral Tablet (Drug)
minirin group
the patients will receive minirin 60 µg PO q8hr with gradual weaning of IV noradrenaline after receiving 4 doses of oral minirin
干预措施: Minirin oral tablet (Drug)
control group
the patients will receive IV nor-adrenaline and are gradually weaning from it according to routine hospital care without adding oral midodrine or oral minirin .
干预措施: Nor-Adrenaline (Drug)
结局指标
主要结局
liberation the patient from IV vasopressors with maintaining hemodynamics.
时间窗: 48 hrs
Blood pressure will be assessed regularly every 15 minutes
次要结局
未报告次要终点
研究者
Ahmed talaat ahmed aly
clinical professor
Assiut University