A comparative study between oral midodrine and placebo for prevention of spinal anaesthesia induced hypotension in lower abdominal surgery.
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2022/01/039702
- Lead Sponsor
- Institute Medical Sciences Banaras Hindu University Varanasi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1-Patients belonging to American Society of Anaesthesiologists (ASA) classification I & II status.2-Patients undergoing for elective lower abdominal surgery.
Exclusion Criteria
1- Patient refusal
2-Patient having contraindication of Midodrine:-
(a)Pheochromocytoma (b) Hypersensitivity to drug (c) severe heart disease (d) Hyperthyroidism (e) Uncontrolled hypertension (f) Increased intracranial tension (g) acute renal disease (h) Hepatic impairment
3-Elderly population or pediatric population
4-During pregnancy and breast feeding
5-Patient having contraindication of subarachnoid block
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of intraoperative Hypotension ( change in systolic blood pressure and diastolic blood pressure)Timepoint: Time from administration of drug or placebo to the end of surgery
- Secondary Outcome Measures
Name Time Method 1-change in Mean arterial blood pressure <br/ ><br>2-Change in Heart Rate <br/ ><br>3-Requirements of Mephentermine and Atropine <br/ ><br>4-Incidence of adverse effects <br/ ><br>(time frame: up to 24 hours surgery)Timepoint: Before the administration of drug and intra-operative at every 3 minute interval for 15 minutes then at every 5 minute interval for 30 minutes then at every 10 minutes interval up to 60 minutes then at every 15 minutes till the end of surgery