A prospective comparison of direct renin inhibitor aliskiren and AT1 receptor blocker in hypertensive patients with chronic kidney disease(CKD).
Not Applicable
Completed
- Conditions
- Hypertension Chronic kidney disease
- Registration Number
- JPRN-UMIN000008615
- Lead Sponsor
- Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1. CKD G5, or dialysis patients. 2. History of hypersensitivity to ARB and/or aliskiren. 3. Pregnant women and/or women who are suspect of pregnancy. 4. Patients taking cyclosporin and/or itraconazole. Patients with history of angioedema 5. Patients judged as inappropriate for the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. BW, obesity, abdominal circumference 2. Clinical blood pressure 3. Home blood pressure 4. ABPM 5. Renal function (urinary protein/albumin/Cr excretion, BUN, eGFR, uric acid, L-FABP) 6. Vascular function(AI, ABI/baPWV), CAVI, FMD) 7. Sympathetic nerve activity 8. Glucose metabolism (FBS, HbA1C, IRI, HOMA-IR) 9. Lipid metabolism (TCHO, LDLC, HDLC, TG) 10.Endocrine (PRA, PAC, urinary aldosteron concentration, BNP) 11.Oxidative stress (h-s CRP, serum pentosidine)
- Secondary Outcome Measures
Name Time Method