Effect of Anodal Transcranial Direct Current Stimulation (tDCS) on Chronic Pain and Motor Cortical Excitability in individuals receiving Buprenorphine Maintenance Treatment – a Pilot, Randomised Controlled Trial - NI

Postgraduate institute of medical education and research chandigarh , india 1600120 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年1月22日

试验速览

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•1 Age: 18-50 years.
•2 Either sex.
•3 A diagnosis of OUD as per DSM-5TR.
•4 Maintained on a well-optimized dose of Buprenorphine for at least 12 weeks prior to the
•intervention period.
•5 Persistent pain symptoms of intensity on Numerical Rating Scale (NRS) 1 to 10) for
•which further increase in buprenorphine dose is not possible due to poor tolerance
•(nausea, headache, sedation) OR patient refuses to increase the dose of buprenorphine
•6 No change in medication is planned during one week of the tDCS treatment course
•(except for benzodiazepines)
•7 Providing written informed consent

•1. The onset of pain symptoms prior to the onset of opioid use disorder
•2. Pain due to secondary causes
•3. Patients with primary psychotic or primary mood disorders.
•4. Patients with a neurological disorder like multiple sclerosis, stroke, epilepsy, or
•encephalopathy due to any cause.
•5. Patients with any intracranial metallic and electric implants.
•6. Patients with comorbid organic brain syndrome and intellectual disability.
•7. Patients with OUD associated with underlying organic illness.
•8. Patients with comorbid substance use disorder (moderate to severe) except Nicotine
•9. Contra-indications for TMS as reflected in the international safety guidelines which
•include metal implants in the face/skull, pacemaker, and primary seizure disorder

发起方

Postgraduate institute of medical education and research chandigarh , india 160012