Postprandial Effects of a High Potassium Meal

Not Applicable

Completed

• Conditions: Hypertension
• Interventions: Other: Low Potassium Meal; Other: High Potassium Meal

• Registration Number: NCT02959931
• Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Brief Summary

The investigators aim to evaluate the acute effects of potassium supplementation achieved by ingestion of potassium rich food, on vascular health.

Detailed Description

Many studies have shown that an increase in potassium through the diet or through potassium pills helps to lower blood pressure. Also, the amount of oral potassium taken can improve how well the participants blood vessels work. These studies have focused on potassium given in the form of a pill. The investigators are interested in the effect of potassium consumed through food sources and how it will effect arterial health and blood pressure. The world health organization (WHO) recommends a K⁺ intake of at least 3510 mg/day from food for adults, excluding those with impaired K⁺ excretion. In this study the investigators aim to provide approximately 75% (approximately 2000 mg) of the total daily recommended intake for potassium in one meal. The investigators do not know whether dietary potassium (not pill form) will acutely improve the arterial health and if it will cause a decrease in blood pressure. The investigators hypothesis to see an improvement in vascular function following a high potassium meal compared to a low potassium meal.

Study Timeline

• Study Start: 2013-06
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Study First Submitted: 2015-12-22
• Study First Submitted QC: 2016-11-07
• Study First Posted: 2016-11-09
• Status Verified: 2020-02
• Last Update Submitted: 2020-02-18
• Last Update Posted: 2020-02-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• 18-80 years
• Normal sinus rhythm
• A diagnosis of hypertension on medical therapy with an ambulatory systolic blood pressure <160 mmHg and diastolic blood pressure <90 mmHg, or a diagnosis of stable coronary artery disease

Exclusion Criteria

• Recent hospital admission due to an cardiovascular events
• Serum K+ concentration >5.0 mmol/L
• Current smoking
• Women who are pregnant
• Diabetic patients - patients receiving insulin therapy
• Glomerular filtration rate < 90mls/min/1.73m2
• On loop diuretic therapy
• Food allergies and/or intolerance to meal items

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Low potassium meal	Low Potassium Meal	In this arm individuals will be provided with a breakfast meal that provides \~540 mg of dietary potassium.
High potassium meal	High Potassium Meal	In this arm individuals will be provided with a breakfast meal that provides \~2400 mg of dietary potassium.

Primary Outcome Measures

Name	Time	Method
Change in Flow Mediated Dilatation	Flow Mediated Dilatation will be assessed over 2 clinic visits, at 3 times points with in each visit; pre-prandial and post-prandial at 60 min and 120 min	Flow Mediated Dilatation is a method used to measure endothelial-dependent regulation of conduit artery tone(Joannides R, 1995).

Trial Locations

Locations (1)

Mount Sinai Hospital; 🇨🇦 Toronto, Ontario, Canada