ipid-induced mitochondrial dysfunction in type 2 diabetes.
Suspended
- Conditions
- Type 2 diabetes, first-degree relatives of type 2 diabetic patients, insulin resistance, mitochondrial function
- Registration Number
- NL-OMON20007
- Lead Sponsor
- Maastricht University Medical Centre, Maastricht, The Netherlands.
- Brief Summary
ower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients. <br> Diabetes, VOL 57, November 2008.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Suspended
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
1. Well controlled type 2 diabetic patients;
2. Normoglycemic first-degree relatives with at least one first-line family member diagnosed with type 2 diabetes;
Exclusion Criteria
1. Uncontrolled hypertension;
2. Active cardiovascular disease;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Ex vivo mitochondrial function;<br /><br>2. In vivo mitochondrial function;<br /><br>3. Insulin sensitivity;<br /><br>4. Fat accumulation in muscle and heart;<br /><br>5. Indirect calorimetry.
- Secondary Outcome Measures
Name Time Method 1. Plasma glucose;<br /><br>2. Plasma insulin;<br /><br>3. Plasma free fatty acids;<br>