Extracorporeal Cytokine Adsorption as Additive Treatment of CAR-T Associated Cytokine Release Syndrome (CRS)
Not Applicable
Recruiting
- Conditions
- CAR-TCytokine Release Syndrome
- Interventions
- Device: Cytosorb
- Registration Number
- NCT04048434
- Lead Sponsor
- Hannover Medical School
- Brief Summary
Patients with severe CAR-T cell associated cytokine release syndrome (CRS) (defined as vasopressor dependent) will be treated with standard of care (SOC) + cytokine adsorption (6hourly for 24 hrs).
Primary endpoint is the change in plasma IL-6 between 0 and 24 hrs.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 34
Inclusion Criteria
- severe CRS (> 3) and / or severe CRES (>3)
AND
- CRS/CRES onset < 6 hrs
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Exclusion Criteria
- Heparine allergy
- contraindication for anticoagulation
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Cyotosorb Cytosorb -
- Primary Outcome Measures
Name Time Method IL-6 change 24 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Hannover Medical School
🇩🇪Hannover, Germany
Universitätsspital Zürich (USZ)
🇨🇭Zürich, Switzerland