Assist Control Versus Pressure Support Modes for Domiciliary Noninvasive Ventilation in Chronic Respiratory Failure

Not Applicable

Completed

• Conditions: Chronic Respiratory Failure
• Interventions: Procedure: respiratory settings

• Registration Number: NCT00189527
• Lead Sponsor: Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche

Brief Summary

Noninvasive ventilation is a therapeutic option in some patients with chronic respiratory failure. Patients usually ventilate during nightime with a domiciliary ventilator either in assist control or in pressure support mode.

The aim of this study is to compare the clinical efficacy and the tolerance of assist control and pressure support modes during domiciliary noninvasive ventilation in patients with chronic respiratory failure.

Detailed Description

The aim of this study is to compare the clinical efficacy and the tolerance of assist control and pressure support modes during domiciliary noninvasive ventilation in patients with chronic respiratory failure.

Study Timeline

• Study First Submitted: 2005-09-12
• Study First Submitted QC: 2005-09-12
• Study First Posted: 2005-09-19
• Study Start: 2006-01
• Primary Completion: 2009-06
• Study Completion: 2009-10
• Status Verified: 2011-02
• Last Update Submitted: 2011-02-16
• Last Update Posted: 2011-02-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Chronic respiratory failure
• Clinical symptoms of chronic alveolar hypoventilation
• PaCO2 ≥ 45 mmHg in case of restrictive pulmonary disorder or PaCO2 ≥ 55 mmHg in case or obstructive pulmonary disorder

Exclusion Criteria

• Clinical exacerbation during the three previous weeks
• Previous treatment by domiciliary non invasive ventilation
• Previous treatment by non invasive ventilation for acute respiratory failure during the 3 previous months
• Bronchiectasis
• Duchenne muscular dystrophy
• Amyotrophic lateral sclerosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
respiratory support	respiratory settings	a mode of ventilation in comparison
Assist Control	respiratory settings	an other mode of ventilation in comparison

Primary Outcome Measures

Name	Time	Method
PaO2	months	Blood gases response to ventilation