Randomized Clinical Trial of the Naturopathic Anti-Inflammatory Diet
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Diabetes Mellitus, Type 2
- Sponsor
- National University of Natural Medicine
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Cytokines
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
The purpose of this study is to determine if the naturopathic Anti-Inflammatory Diet results in reduced inflammation and a better response by the immune system when compared to a standard diabetic diet based on the current American Diabetes Association guidelines.
Detailed Description
This study will test the effects of two different diets on the immune system and inflammation in diabetes and pre-diabetes. These diets are the "Anti-Inflammatory Diet" (AI Diet) used by many naturopathic doctors and a standard diabetic diet based on the American Diabetes Association recommendations (ADA Diet). The AI diet excludes wheat, dairy products, eggs, red meat, caffeine, alcohol, peanuts and certain fruits and vegetables. The ADA diet includes most foods but controls the amount of each of the food groups. Naturopathic physicians often use healthful diets to treat diseases but many of these diets have not been compared to usual medical diet treatments. We will be looking at blood markers that show how the immune system responds to the different diets. We are expecting that the AI diet will result in less inflammation and a better response by the immune system than the ADA diet. We will also be looking at levels of blood lipids and glucose to see any effects on these risk factors.
Investigators
Eligibility Criteria
Inclusion Criteria
- •BMI: 25-45 kg/m2
- •Age 18-75 yrs
- •Diagnosed with type 2 diabetes or pre-diabetes
- •At risk for type 2 diabetes. Must meet 2 of the following 3 criteria: BMI 30-45 kg/m2, age 50 or older, and/or family history of type 2 diabetes
- •Fasting blood glucose of 100-200 mg/dl
- •Provide informed consent
Exclusion Criteria
- •Current major debilitating mental or physical illness that would interfere with participation (as determined by the participant's medical history)
- •Taking diabetic medication other than sulfonylurea
- •Taking Gymnema silvestra (a naturopathic diabetes treatment)
- •Taking medications that have anti-inflammatory affects (lipid lowering agents, NSAIDS, COX 2 inhibitors, aspirin, HRT, oral contraceptives, testosterone, seizure medications)
- •Taking weight loss medications
- •Severe renal, hepatic, or heart disease
- •Triglycerides \>500 mg/dL
- •Pregnancy or lactation
- •Current excessive use of alcohol
- •Current/recent chronic use of recreational drugs
Outcomes
Primary Outcomes
Cytokines
Time Frame: 13 weeks
Secondary Outcomes
- Glucose(113 weeks)
- Weight(13 weeks)
- Lipids(13 weeks)