Mindfulness Based Compassionate Living in Recurrent Depression

Not Applicable

Completed

• Conditions: Recurrent Depression
• Interventions: Behavioral: Mindfulness Based Compassionate Living

• Registration Number: NCT02059200
• Lead Sponsor: Radboud University Medical Center

Brief Summary

Since a few years, Mindfulness Based Cognitive Therapy (MBCT) has been used as treatment for patients suffering from recurrent depression. Though a number of studies show that MBCT is effective in this population and MBCT reduces the chances of relapse/recurrence in recurrent depressive patients, the chance of a new depression developing after end of treatment is still considerable. Ergo, there is room for improvement.

Especially the development of a non-judging or compassionate attitude towards all experience seems to mediate the treatment effect. It is therefore our expectation that a follow-up intervention that focuses specifically on self-compassion could prove very useful in elaborating on the effects of MBCT.

The research question of this research is therefore: what is the effect of compassion training in people suffering from recurrent depression who have already received MBCT training?

Detailed Description

Not available

Study Timeline

• Study Start: 2013-07
• Study First Submitted: 2014-01-30
• Study First Submitted QC: 2014-02-10
• Study First Posted: 2014-02-11
• Primary Completion: 2015-05
• Study Completion: 2015-11
• Status Verified: 2023-04
• Last Update Submitted: 2023-04-14
• Last Update Posted: 2023-04-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 122

Inclusion Criteria

1. Recurrent depression according to the DSM-IV criteria.
2. Having participated in an MBCT training (>= 4 sessions)

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Exclusion Criteria

1. One or more previous (hypo)manic episodes according to DSM-IV criteria.
2. Primary psychotic disorder, e.g. schizophrenia or delusions.
3. Clinically relevant neurological conditions (e.g. brain trauma or dementia) or somatic conditions (e.g. cancer, AIDS) that could be related to the depression.
4. Current alcohol and/or drug abuse.
5. Use of high dosages of benzodiazepines.
6. Recent electro convulsive therapy (ECT) (less than 3 months ago).
7. Problems impeding participating in a group, such as severe borderline personality disorder.
8. No prior experience with MBCT.
9. Problems impeding completing the questionnaires, such as cognitive dysfunctions (only assessed if suspected).
10. Subnormal intelligence (IQ < 80) (only assessed if suspected).

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
MBCL + TAU	Mindfulness Based Compassionate Living	This cohort receives the Mindfulness Based Compassionate Living program in addition to treatment as usual.

Primary Outcome Measures

Name	Time	Method
Beck Depression Inventory-II	1 year	The BDI-II measures depression symptoms. Measurements will be taken at baseline, end of treatment/control and follow up.

Secondary Outcome Measures

Name	Time	Method
Five Facet Mindfulness Questionnaire	1 year	The FFMQ measures mindfulness skills. Measurements will be taken at baseline, end of treatment/control and follow-up.
The Acceptance and Action Questionnaire-II	1 year	The AAQ-II measures Experiential Avoidance. Measurements will be taken at baseline, end of treatment/control and follow-up.
Self-Compassion Scale	1 year	The Self-Compassion Scale measures Self-Compassion. Measurements will be taken at baseline, end of treatment/control and follow-up.
Fears of Compassion Scale (3)	1 year	The FoCS (3) measures fear of Self-Compassion. Measurements will be taken at baseline, end of treatment/control and follow-up.
The Ruminative Response Scale	1 year	The RRS measures Rumination. Measurements will be taken at baseline, end of treatment/control and follow-up.
The Childhood Trauma Questionnaire	Baseline	The CTQ measures Childhood Adversity. Measurements will be taken at baseline only.
Types of Positive Affect Scale	1 year	The TPAS measures Positive Affect. Measurements will be taken at baseline, end of treatment/control and follow-up.
The World Health Organization Quality of Life Scale	1 year	The WHO-QoL measures Quality of Life. Measurements will be taken at baseline, end of treatment/control and follow-up.

Trial Locations

Locations (1)

University Medical Center Nijmegen; 🇳🇱 Nijmegen, Gelderland, Netherlands