Central Hemodynamics
- Conditions
- Hypertension
- Interventions
- Other: Optimization of blood pressure according to guidelines
- Registration Number
- NCT01837784
- Lead Sponsor
- Luzerner Kantonsspital
- Brief Summary
Guidelines recommend measuring end organ damage and in particular arterial stiffness in patients with hypertension. However, until now it was not possible to measure arterial stiffness with the use of simple methods. Recently, novel and innovative devices offering determination of arterial stiffness and central hemodynamics from simple and non-invasive arm cuff measurements have now become available. This study therefore evaluates the value of non-invasively measured arterial stiffness and central hemodynamics for guiding antihypertensive treatment in selected patient populations (i.e. elderly patients, patients with diabetes mellitus, patients with heart failure, and patients with resistant hypertension).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- Patients >70 years (elderly cohort)
- Patients with diabetes mellitus (diabetes cohort)
- Patients with heart failure (heart failure cohort)
- Patients with resistant hypertension (resistant hypertension cohort)
- Patient refuses study participation
- Severe renal failure
- Reduced life expectancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Elderly patients Optimization of blood pressure according to guidelines - Patients with diabetes mellitus Optimization of blood pressure according to guidelines - Patients with heart failure Optimization of blood pressure according to guidelines - Patients with resistant hypertension Optimization of blood pressure according to guidelines -
- Primary Outcome Measures
Name Time Method Arterial stiffness and central hemodynamics 3 months Non-invasive measurement of arterial stiffness and central hemodynamics with the Tensiomed Arteriograph device
Cognitive function 3 months Measurement with Mini Mental State Exam and Verbal Recall Test
- Secondary Outcome Measures
Name Time Method Physical function 3 months Measurement with gait speed, hand grip test and physical activity questionnaire
Orthostatic hypotension and falls 3 months Measurement with blood pressure recordings and structured questionnaire
Renal failure 3 months Creatinine measurement
Trial Locations
- Locations (1)
Luzerner Kantonsspital
🇨ðŸ‡Luzern, Switzerland