MedPath

Central Hemodynamics

Conditions
Hypertension
Interventions
Other: Optimization of blood pressure according to guidelines
Registration Number
NCT01837784
Lead Sponsor
Luzerner Kantonsspital
Brief Summary

Guidelines recommend measuring end organ damage and in particular arterial stiffness in patients with hypertension. However, until now it was not possible to measure arterial stiffness with the use of simple methods. Recently, novel and innovative devices offering determination of arterial stiffness and central hemodynamics from simple and non-invasive arm cuff measurements have now become available. This study therefore evaluates the value of non-invasively measured arterial stiffness and central hemodynamics for guiding antihypertensive treatment in selected patient populations (i.e. elderly patients, patients with diabetes mellitus, patients with heart failure, and patients with resistant hypertension).

Detailed Description

Not available

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
100
Inclusion Criteria
  • Patients >70 years (elderly cohort)
  • Patients with diabetes mellitus (diabetes cohort)
  • Patients with heart failure (heart failure cohort)
  • Patients with resistant hypertension (resistant hypertension cohort)
Read More
Exclusion Criteria
  • Patient refuses study participation
  • Severe renal failure
  • Reduced life expectancy
Read More

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Elderly patientsOptimization of blood pressure according to guidelines-
Patients with diabetes mellitusOptimization of blood pressure according to guidelines-
Patients with heart failureOptimization of blood pressure according to guidelines-
Patients with resistant hypertensionOptimization of blood pressure according to guidelines-
Primary Outcome Measures
NameTimeMethod
Arterial stiffness and central hemodynamics3 months

Non-invasive measurement of arterial stiffness and central hemodynamics with the Tensiomed Arteriograph device

Cognitive function3 months

Measurement with Mini Mental State Exam and Verbal Recall Test

Secondary Outcome Measures
NameTimeMethod
Physical function3 months

Measurement with gait speed, hand grip test and physical activity questionnaire

Orthostatic hypotension and falls3 months

Measurement with blood pressure recordings and structured questionnaire

Renal failure3 months

Creatinine measurement

Trial Locations

Locations (1)

Luzerner Kantonsspital

🇨🇭

Luzern, Switzerland

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