Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan

Phase 4

• Conditions: Antihypertensive Drugs; Left Atrial Volume; Hypertensive Heart Disease; Diastolic Function; Renin Angiotensin System
• Interventions: Drug: irbesartan; Drug: ramipril

• Registration Number: NCT00517322
• Lead Sponsor: Università degli Studi dell'Insubria

Brief Summary

Aim of the study is to compare in hypertensive patients the effect of one year therapy with ACE-inhibitor (RAMIPRIL) or angiotensin II receptor blocker (IRBESARTAN) on left atrial remodelling and diastolic function.

Detailed Description

Not available

Study Timeline

• Status Verified: 2007-08
• Study Start: 2007-08
• Study First Submitted: 2007-08-15
• Study First Submitted QC: 2007-08-15
• Last Update Submitted: 2007-08-15
• Study First Posted: 2007-08-16
• Last Update Posted: 2007-08-16
• Study Completion: 2010-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

·

• mild to moderate essential hypertension
• no antihypertensive treatment
• good quality echocardiogram

Exclusion Criteria

• cardiovascular diseases (AMI, stroke o TIA)
• heart failure, valvular heart disease
• diabetes
• secondary hypertension
• atrial fibrillation
• hepatic and renal severe failure
• pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
2	irbesartan	treatment with irbesartan
1	ramipril	treatment with ramipril

Primary Outcome Measures

Name	Time	Method
diastolic function	one year
left atrial volume	one year

Secondary Outcome Measures

Name	Time	Method
systolic and diastolic blood pressure	one year

Trial Locations

Locations (1)

University of Insubria-Department of Clinical Medicine; 🇮🇹 Varese, Italy