Evaluating the Effect of Chronic Antihypertensive Therapy on New Onset Atrial Fibrillation and Clinical Outcomes in Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 133
- 试验地点
- 1
- 主要终点
- Cumulative percent (%) of patients with new onset atrial fibrillation at 48 hours
研究概览
简要总结
Retrospective two-cohort study to determine the effect of chronic antihypertensive therapy on new onset atrial fibrillation and clinical outcomes in septic shock.
详细描述
This will be a retrospective two-cohort study to determine the effect of chronic antihypertensive therapy on new onset atrial fibrillation and clinical outcomes in septic shock. The two cohorts will be septic shock patients that were: 1) not on either a chronic β-blocker or angiotensin-converting-enzyme inhibitor (ACE inhibitor) or 2) on a chronic β-blocker, on chronic ACE-Inhibitor, or on both chronic β-blocker and ACE-inhibitor
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients 18 years of age or older
- •Diagnosis of septic shock requiring vasopressor therapy (norepinephrine, epinephrine, phenylephrine, dopamine, or vasopressin)
- •Admitted to the medical intensive care unit (MICU) at Rush University Medical Center (RUMC)
- •Time frame: 01/01/2012 to 07/1/2016
排除标准
- •Pregnant patients
- •Transfer from outside hospital on vasopressors
- •Admitted to MICU in cardiopulmonary arrest
- •Prior arrest within 24 hours of admission to RUMC
结局指标
主要结局
Cumulative percent (%) of patients with new onset atrial fibrillation at 48 hours
时间窗: 48 hours
New onset atrial fibrillation defined as atrial fibrillation not present on admission to MICU
次要结局
- Duration of mechanical ventilation(During admission)
- In hospital mortality(During admission)
- Heart rate > 100(48 hours)
- New onset of other arrhythmias(48 hours)
- Peak lactate(48 hours)
- 28 day mortality(28 days after discharge)
- New onset atrial fibrillation for patients on other antiarrhythmics(24 and 48 hours)
- Cumulative percent (%) of patients with new onset atrial fibrillation at 24 hours(24 hours)
- 90 day mortality(90 days after discharge)