Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 133
- 试验地点
- 1
- 主要终点
- Total Vasopressor Dose
研究概览
简要总结
Retrospective study to examine the effects of chronic antihypertensive medications on vasopressor dosing in septic shock
详细描述
This will be a retrospective four-cohort study. The four cohorts will be septic shock patients that were: 1) not on either a chronic β-blocker or chronic angiotensin-converting-enzyme inhibitor (ACE-Inhibitor), 2) on chronic β-blocker, 3) on ACE-Inhibitor, and 4) on both chronic β-blocker and ACE-inhibitor
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients 18 years of age or older
- •Diagnosis of septic shock requiring vasopressor therapy (norepinephrine, epinephrine, phenylephrine, dopamine, or vasopressin)
- •Admitted to an intensive care unit (ICU) at Rush University Medical Center (RUMC)
- •Time frame: 01/01/2012 to 07/1/2016
排除标准
- •Pregnant patients
- •Transfer from outside hospital on vasopressors
- •Admitted in cardiopulmonary arrest
- •Prior arrest within 24 hours of admission to RUMC
结局指标
主要结局
Total Vasopressor Dose
时间窗: 48 hours
The primary objective is to determine the effect of chronic β-blocker or ACE-inhibitor on vasopressor dosing in the first 48 hours of septic shock. Vasopressor types and cumulative doses including: norepinephrine, epinephrine, phenylephrine, dopamine, and vasopressin. Epinephrine, phenylephrine, and dopamine will be converted to norepinephrine equivalents in concordance with other literature: 100 mcg dopamine equivalent to 1 mcg norepinephrine, 1 mcg epinephrine equivalent to 1 mcg norepinephrine, and 2.2 mcg phenylephrine equivalent to 1 mcg norepinephrine
次要结局
- 30 mL/kg Fluid Within 6h(48 hours)
- Inotrope Use(6, 12, 24, 48 hours)
- Hydrocortisone Use(6, 12, 24, 48 hours)
- Cumulative Vasopressor Dose for Patients Receiving Other Antihypertensives(6, 12, 24, 48 hours)
- 6-hour Vasopressor Dose(6 hours)
- 12-hour Vasopressor Dose(12 hours)
- 24-hour Vasopressor Dose(24 hours)