Transversus Abdominus Plane (TAP) Block Catheters vs Liposomal Bupivacaine for Pain Control After Colorectal Surgery: A Prospective Randomized Control Trial
Overview
- Phase
- Phase 4
- Intervention
- Exparel
- Conditions
- Colorectal Surgery
- Sponsor
- University of California, Davis
- Enrollment
- 86
- Locations
- 1
- Primary Endpoint
- Mean Opioid Consumption in Morphine Opioid Equivalents in mg
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
This is a prospective randomized study designed to compare the pain control from a single shot of liposomal bupivacaine (Exparel) against transversus abominus plane (TAP) catheters with ropivicaine bolus in patients undergoing elective colorectal surgery.
Detailed Description
At UC Davis, it is standard practice to place TAP blocks with catheters for adult colorectal surgery patients for perioperative pain control. This practice, however, is resource intensive, adds the risk of catheter-related complications, and adds increased burden to patients by requiring them to be tethered to 2 catheters. An alternative TAP can be performed using a single shot of liposomal bupivacaine (Exparel), an extended release local anesthetic that is FDA-approved for surgical plane infiltration including TAP blocks. With this prospective study, we seek to improve patient care at UC Davis and educate other institutions through the use of concrete data comparing these 2 treatment options.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled for elective colorectal surgery with Dr. Linda Farkas
Exclusion Criteria
- •Patients under 18 years of age
- •Patient over 90 years of age
- •Pregnancy
- •Prisoners
- •Patients unable to provide consent
- •Patients on systemic anticoagulation therapy
- •Patients with an allergy to local anesthetics
Arms & Interventions
Group 1
Single injection of Exparel
Intervention: Exparel
Group 2
Injection of Ropivicaine (Naropin) bolus and placement of Ropivicaine catheters
Intervention: Ropivacaine
Outcomes
Primary Outcomes
Mean Opioid Consumption in Morphine Opioid Equivalents in mg
Time Frame: 48 hours from start of surgery
Anticipate superior efficacy and pain control with liposomal bupivacaine TAP blocks measured by use of opioids (measured in oral morphine equivalents) in the first 48 hours following surgery Will use opioid consumption in morphine equivalents as a comparison