Study on monoamine oxidase B (MAO-B) distribution differences associated with MAO-B inhibitors and smoking in Parkinson's disease
- Conditions
- Parkinson's disease (PD)
- Registration Number
- JPRN-UMIN000049442
- Lead Sponsor
- Cyclotron and Radioisotope Center, Tohoku University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 57
Not provided
(1) Administration of irreversible MAO-B inhibitors, Habitual smoking (within 1 year of entry) (2) Being in the period of pregnancy, possible pregnancy, breast feeding, within 28 days after child birth (3) Severe allergic reactions to drugs and foods (4) Psychiatric disorders, which may make the participation to this study difficult (5) Taboo conditions for MRI examinations (cardiac pacemaker, intracorpoporial metals, etc. to be checked with questionnaire in advance) (6) Systemic circulatory and metabolic disorders as well as organ dysfuctions, such as diabetes melitus, hypertension, endocrinolog ical disorders, congestive heart failure, angina petoris, severe renal dysfunctions with Ccr<30mL/min or under plasmapheresis) (7) Past history of malignant diseases within 1 year of entry (8) Any sociomedial conditions, which may make the participation to this study difficult
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method SUV ratio (SUVR)
- Secondary Outcome Measures
Name Time Method