The Brain Activation During Different Motor Patterns in Healthy Adults

Completed

• Conditions: Neurosciences

• Registration Number: NCT04868929
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

This study aims to investigate the brain activation during different motor patterns, including motor execution (ME), motor imagery (MI), action observation (AO) and mirror visual feedback (MVF). In addition, the relations between brain activation and motor performance will also be explored. This study includes two parts, which are upper limb and lower limb part. While executing all the tasks, brain activation in primary motor cortex(M1), premotor cortex(PMC), and supplementary motor cortex(SMA) will be monitored by functional near-infrared spectroscopy. One-way ANOVA with repeated measure will be used to detect the differences of brain activation level between each mode. Pearson correlation coefficient will be used to determine the relations of brain activation and motor performance.

Detailed Description

In upper limb part, subjects will be instructed to execute functional reaching task in ME, MI, AO, and MVF mode. During ME mode, motor performance including maximum speed, maximum acceleration, and jerk will be collected simultaneously. In the lower limb part, subjects will be instructed to walking over ground in ME, MI, and AO mode. During ME mode, the temporal and spatial gait parameters, including speed, stride time, cadence, and stride length will be collected.

Study Timeline

• Study First Submitted: 2021-04-25
• Study First Submitted QC: 2021-04-27
• Study Start: 2021-05-01
• Study First Posted: 2021-05-03
• Status Verified: 2022-06
• Primary Completion: 2022-08-07
• Study Completion: 2022-08-07
• Last Update Submitted: 2023-02-20
• Last Update Posted: 2023-02-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Brain activities over primary motor cortex	Day 1	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Brain activities over premotor cortex	Day 1	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.
Brain activities over supplementary motor area	Day 1	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.

Secondary Outcome Measures

Name	Time	Method
Motor performance of upper limb -maximum speed	Day 1	cm/s
Motor performance of lower limb - gait speed	Day 1	cm/s
Motor performance of lower limb - cadence	Day 1	steps
Motor performance of lower limb - stride length	Day 1	cm
Motor performance of upper limb -maximum acceleration	Day 1	cm/s\^2
Motor performance of upper limb - jerk	Day 1	cm/s\^3
Motor performance of lower limb - stride time	Day 1	second

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan