Assessment of Brain Activation With Different Mirror Therapy Tasks - Contribution of EEG and fNIRS in Healthy Subjects.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Healthy
- Sponsor
- Centre Hospitalier Régional d'Orléans
- Enrollment
- 38
- Locations
- 1
- Primary Endpoint
- Change in the EEG spectral alpha and beta-band power (8-12 and 12-30Hz) during movement (Event related Desynchronisation)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The purpose of this study is to investigate the cerebral activation during visual motor simulation in healthy subjects in 3 conditions: observation (OBS), observation and imagination (OBS-IM) and observation and realization (OBS-REAL). The investigators goal is to compare cerebral activation during the three different tasks using EEG and fNIRS.
Detailed Description
Mirror therapy is a rehabilitation technique that has been shown to be effective in restoring upper limb motor skills in patients with stroke. However, it comes up against certain constraints of clinical use such as installation difficulties or the obligation of symmetrical bilateral work. These constraints can be limited by the use of so-called 2nd generation virtual mirror therapy technologies. It is therefore likely that these new technologies will improve the feasibility and effectiveness of mirror therapy in rehabilitation. The brain mechanisms involved in virtual mirror therapy are not yet fully understood. EEG (Electroencephalography) and fNIRS (functional Near Infra Red Spectroscopy) are two functional method that allows to study the cerebral cortex changes during different tasks (like fMRI). These techniques therefore makes it possible to study brain activation under more ecological conditions than fMRI and are therefore particularly suitable for exploring rehabilitation techniques. This research aims to study and compare in healthy subjects, using EEG and fNIRS, the brain regions involved in three tasks using a virtual mirror therapy device (IVS4 apparatus ; Dessintey, France) implying lower limb control. The protocol has 3 conditions : observation (OBS), observation and imagination (OBS-IM) and observation and realization (OBS-REAL). The order of the 3 conditions will then be randomized to avoid potential biases linked to the sequence of conditions. The EEG recording will used the 32 channels ENOBIO apparatus. The fNIRS will used the Brite MKII apparatus
Investigators
Eligibility Criteria
Inclusion Criteria
- •Subjects aged 18 to 75 years
- •Sufficient command of the French language to understand the instructions
- •No known neurological medical history
- •With social security coverage
- •Right-handed subjects with a laterality test of Edinburgh QL\> 40 (Oldfield 1971)
Exclusion Criteria
- •Minor subjects
- •Adults under guardianship
- •Adults under guardianship
- •Pregnant or breastfeeding women
- •Subjects who have objected to participating in the study
Outcomes
Primary Outcomes
Change in the EEG spectral alpha and beta-band power (8-12 and 12-30Hz) during movement (Event related Desynchronisation)
Time Frame: Day 0
Beta desynchronization in dB normalized to a baseline before the movement.
Change in the beta band after movement (Beta-Rebound).
Time Frame: Day 0
Beta Rebound power in dB normalized to a baseline before the movement.
Secondary Outcomes
- Mean change in the concentration of deoxyhemoglobin during the task(Day 0)
- Mean change in the concentration of oxyhemoglobin during the task(Day 0)