Effects of the Visual Stimulation on the Motor and Visual Cortex in Migraneurs With and Without Aura
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Migraine Disorders
- Sponsor
- Universidade Federal de Pernambuco
- Enrollment
- 59
- Locations
- 1
- Primary Endpoint
- Changes on motor evoked potentials
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The aim of this study is to investigate the motor and visual cortex excitability in response to visual stimulation of migraineurs with and without aura compared to healthy individuals. For this purpose, electrical cortical activity of migraineurs will be compared to healthy volunteers.
Detailed Description
A cross sectional study to compare the best approach to migraineurs evaluation. For this, healthy individuals, after reading and signing the free and informed consent will be submitted to a single session to obtain the normal neurophysiological endpoints and thus compare with those obtained in individuals with migraineurs volunteers. All volunteers (healthy and migraineurs) will be submitted to a neurophysiological evaluation through transcranial magnetic stimulation (TMS) and electroencephalography (EEG). A visual stimulation will be delivered during the assessment of habituation through visual evoked potential volunteers (VEP-habituation) and the following measures will be evaluated before and after visual stimulation: (i) Motor Evoked Potentials (MEP); (ii) Motor Threshold (MT); (iii) Short Interval Cortical Inhibition (SICI); (iv) Intracortical Facilitation (lCF) and (v) Phosphene Threshold (PT).
Investigators
Kátia Monte-Silva
Principal Investigator
Universidade Federal de Pernambuco
Eligibility Criteria
Inclusion Criteria
- •Ages: 18-55 years
- •Gender: Both
- •Prior headache report
Exclusion Criteria
- •Pregnant women;
- •Pacemaker;
- •History of seizures;
- •Metallic implants in the head;
- •Patients with clinical evidence of brain injuries;
- •Chronic pain associated to others diseases;
- •Use of neuroleptic medications
Outcomes
Primary Outcomes
Changes on motor evoked potentials
Time Frame: one day (Before and after visual stimulation)
to measure MEP, the intensity of the magnetic stimulator will be adjusted to 120% of rest motor threshold and 10 stimuli will be registered. For evaluation volunteers will be instructed to sit in a chair and get into a comfortable position. Initially, single-pulse TMS will be administered over the motor cortex to determine the cortical representation area of the first dorsal interosseous muscle (FDI). For all evaluations the same figure-eight coil is used, in order to avoid measurement bias. Amplitude means of evoked potentials will determine the MEP.
Secondary Outcomes
- Changes on short interval intracortical inhibition(one day (Before and after visual stimulation))
- Changes on intracortical facilitation(one day (Before and after visual stimulation))
- Changes from phosphene threshold(one day (Before and after visual stimulation))
- Habituation of Visual Evoked Potentials evaluated by Electroencephalography(one day (during visual stimulation))