Evaluating the efficacy of continuous renal replacement therapy using the oXiris membrane on inflammatory mediator clearance in patients with septic shock.
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 No limit（—）
- 性别
- All
入选标准
- •Age 18 years or older.
- •Diagnosed with septic shock according to the Sepsis-3 consensus definition.
- •Sequential Organ Failure Assessment (SOFA) score >=
- •Requiring continuous vasopressor support (Noradrenaline dose >= 0.2 mcg/kg/min).
- •Having a clinical indication for Continuous Renal Replacement Therapy (CRRT).
排除标准
- •Refusal to participate or lack of informed consent from the patient or their legally authorized representative.
- •Imminent death or expected mortality within the first 24 hours of ICU admission.
- •Patients currently receiving Extracorporeal Membrane Oxygenation (ECMO) support.
- •Pregnant women.
研究组 & 干预措施
Patients in this intervention group will undergo Continuous Renal Replacement Therapy (CRRT) using the highly adsorptive oXiris membrane (Baxter). This membrane is designed to provide standard renal support while additionally removing cytokines and endotoxins from the bloodstream. The therapy will be initiated upon diagnosis of septic shock with an indication for CRRT. The oXiris filter will be routinely changed every 12 to 24 hours during the first 72 hours of treatment to maximize its adsorptive capacity, or as dictated by clinical requirements such as circuit clotting or high transmembrane pressures. Adherence to the protocol will be monitored through daily clinical audits and electronic medical records, ensuring the filter changes and CRRT parameters are executed as specified. Any deviations from the treatment protocol will be documented in the patient’s Case Report Form (CRF).
干预措施: Patients in this intervention group will undergo Continuous Renal Replacement Therapy (CRRT) using the highly adsorptive oXiris membrane (Baxter). This membrane is designed to provide standard renal support while additionally removing cytokines and endotoxins from the bloodstream. The therapy will be initiated upon diagnosis of septic shock with an indication for CRRT. The oXiris filter will be routinely changed every 12 to 24 hours during the first 72 hours of treatment to maximize its adsorptive capacity, or as dictated by clinical requirements such as circuit clotting or high transmembrane pressures. Adherence to the protocol will be monitored through daily clinical audits and electronic medical records, ensuring the filter changes and CRRT parameters are executed as specified. Any deviations from the treatment protocol will be documented in the patient’s Case Report Form (CRF).