Association of Oral Lichen Planus and Thyroid Disease

Completed

• Conditions: Oral Lichen Planus; Thyroid Diseases
• Interventions: Diagnostic Test: determination of thyroid hormones and antibodies

• Registration Number: NCT04523077
• Lead Sponsor: University of Zagreb

Brief Summary

Thyroid disease is a common endocrine disorder. Oral lichen planus (OLP) is a chronic autoimmune disease that occurs on the oral mucosa in 1-2% of the general population.The purpose of this study was to determine whether there is an association between thyroid disease and oral planus lichen in the population of our patients. In the last few years, a couple of studies have been published in the world literature that have studied the possible association of these diagnoses in different populations. Most of the results showed a higher prevalence of thyroid disease in the population of lichen patients, compared with patients without lichen, although some results are contradictory. Some authors believe that the onset of OLP precedes thyroid dysfunction. In the population of Croatian patients with lichen, no research has been done to study the possible connection between these two diseases. The obtained results could help clarify whether there is a connection between these two diagnoses in the population of our lichen patients and enable earlier detection of patients with thyroid hypofunction.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Primary Completion: 2020-04-30
• Study Completion: 2020-04-30
• Status Verified: 2020-08
• Study First Submitted: 2020-08-18
• Study First Submitted QC: 2020-08-18
• Study First Posted: 2020-08-21
• Last Update Submitted: 2020-08-22
• Last Update Posted: 2020-08-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

• for test group: female patients of the Department of Oral Medicine School of Dental Medicine University of Zagreb with clinically and histopathologically confirmed oral lichen planus
• for control group: female patients of the Department of Oral Medicine School of Dental Medicine University of Zagreb, without oral lichen planus or other immune disorders; age matched to test group

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Exclusion Criteria

• male patients; female patients with immune disorders; female patients which are not age-matched to test group

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control	determination of thyroid hormones and antibodies	Female patients of the Department of Oral Medicine without oral lichen planus or other immune disorders
Oral lichen planus	determination of thyroid hormones and antibodies	Female patients of the Department of Oral Medicine with oral lichen planus

Primary Outcome Measures

Name	Time	Method
The prevalence of thyroid diseases in patients with oral lichen planus	January 2020-April 2020	to determine whether there is a higher prevalence of thyroid disease in patients with oral lichen

Trial Locations

Locations (1)

School of Dental Medicine, University of Zagreb; 🇭🇷 Zagreb, Croatia