PEEP-induced Changed in RRI as Physiological Background of Ventilator-induced Kidney Injury

Completed

• Conditions: Respiration, Artificial; Respiratory Distress Syndrome, Adult; Acute Kidney Injury
• Interventions: Procedure: PEEP changes

• Registration Number: NCT03969914
• Lead Sponsor: Università degli Studi di Ferrara

Brief Summary

The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. Many parameters have been described as influential on the values of renal RI. Mechanical ventilation is associated with significant increases in the risk of acute kidney injury (AKI). Ventilator-induced kidney injury (VIKI) is believed to occur due to changes in hemodynamics that impair renal perfusion. The investigators hypothesized that patients who need mechanical ventilation should have a different response in RRI when different levels of Positive end expiratory pressure (PEEP) are applied. Investigators wish to describe changing in RRI due to changes in PEEP and to verify whether these changes could partially explain the occurrence of VIKI

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-01
• Study First Submitted: 2019-05-28
• Study First Submitted QC: 2019-05-28
• Study First Posted: 2019-05-31
• Primary Completion: 2020-05-01
• Study Completion: 2020-06-15
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-27
• Last Update Posted: 2022-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 105

Inclusion Criteria

• Patients admitted to ICU with expected mechanical ventilation >48h

Exclusion Criteria

• Ultrasound RRI evaluation non available
• Patients with arrhythmia
• Pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Critically ill ventilated patients	PEEP changes	Patients admitted to ICU with expected mechanical ventilation \>48h

Primary Outcome Measures

Name	Time	Method
Occurence of AKI	once a day until day 7	AKI will be defined according to Kidney Disease: Improving Global Outcomes (KDIGO) criteria

Secondary Outcome Measures

Name	Time	Method
Change in RRI at different level of PEEP	One a day until day 5	To compare median difference of RRI at PEEP 5 and PEEP 15 in patients who will develop (or not) AKI

Trial Locations

Locations (2)

Università di Ferrara; 🇮🇹 Ferrara, Italy

Università di Siena; 🇮🇹 Siena, Italy