Effects of Red Blood Cells Transfusion on Renal Blood Flow

Completed

• Conditions: Anemia; Acute Kidney Injury; Fluid Overload; Transfusion-Associated Circulatory Overload
• Interventions: Other: Crystalloids infusion; Other: Transfusion

• Registration Number: NCT04194047
• Lead Sponsor: Università degli Studi di Ferrara

Brief Summary

The renal Doppler resistive index (RRI) is a noninvasive tool that has been used to assess renal perfusion in the intensive care unit (ICU) setting. It is associated with the occurrence of acute kidney injury (AKI). Many parameters have been described as influential on the values of renal RI. Red blood cell (RBC) transfusion were shown to be able to increase renal oxygenation in animal model, whereas crystalloid resuscitation did not. We sought to describe the different effect of crystalloids infusion and RBC transfusion on renal blood flow, as evaluated with doppler ultrasound

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-12-08
• Study First Submitted QC: 2019-12-08
• Study First Posted: 2019-12-11
• Study Start: 2020-03-01
• Status Verified: 2022-09
• Primary Completion: 2022-09-01
• Study Completion: 2022-09-01
• Last Update Submitted: 2022-09-08
• Last Update Posted: 2022-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

• Age > 18 and < 90
• Hemoglobin ≥7 and ≤ 10 g/dl

Exclusion Criteria

• Ultrasound RRI evaluation non available
• Patients with arrhythmia
• Pregnancy
• Refusal to give consent
• History of renal transplantation
• Central venous access in superior vena cava not available Critical active bleeding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
crystalloids group	Crystalloids infusion	Patients who received fluid resuscitation with crystalloids
RBC group	Transfusion	Patients who received RBC transfusion

Primary Outcome Measures

Name	Time	Method
Change Renal Venous Stasis Index (RSVI) after intervention	after 60 minute from intervention	To compare change in RSVI after intervention between groups. Under physiological conditions, the index is zero. Higher values means worse outcome.
Change in renal resistivity index (RRI) after intervention	after 60 minute from intervention	To compare change in RRI after intervention between groups. Values over\>0.70 are considered pathological. Higher values means worse outcome.

Secondary Outcome Measures

Name	Time	Method
Occurence of AKI	Once a day for 7 days	Occurence of AKI as defined by Kidney Disease: Improving Global Outcomes (KDIGO)
Variation in renal resistivity index (RRI)	after 24 hours from intervention	To compare change in RRI after intervention between groupsValues over\>0.70 are considered pathological. Higher values means worse outcome.
Variation in Renal Venous Stasis Index (RSVI)	after 24 hours from intervention	To compare change in RSVI after intervention between groups. Under physiological conditions, the index is zero. Higher values means worse outcome.

Trial Locations

Locations (1)

Università di Ferrara; 🇮🇹 Ferrara, Italy