Safety and efficacy of intra-articular injection of platelet rich plasma in patients with ankle osteoarthritis
- Conditions
- Ankle osteoarthritis
- Registration Number
- JPRN-UMIN000028601
- Lead Sponsor
- Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University
- Brief Summary
o serious adverse effects were observed related with intra-articular injection of platelet rich plasma. The VAS scores significantly decreased from baseline to 4, 12, and 24 weeks after treatment. The JSSF scale score and the pain and pain-related subscale score of the SAFE-Q significantly improved from baseline to 12 weeks after treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 20
Not provided
1 Anemia (hemoglobin levels less than 11mg/dl) 2 Thrombocytopenia (platelet levels less than 150*103/ul) 3 History of ankle surgery or ankle fracture within the past 12 months 4 Treatment with steroid or hyaluronic acid injections within the past 6 months 5 Treatment with oral anticoagulant 6 Systemic inflammatory disease (eg rheumatoid arthritis) 7 Renal failure 8 Hepatic failure 9 Diabetes mellitus (HbA1c more than 9.0) 10 Psychological disease 11 Pregnancy 12 Infection of the ankle 13 Cancer or malignant lesions
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method