Remifentanil and Nitroprusside for Controlled Hypotension

Not Applicable

Completed

• Conditions: Hypotension, Controlled
• Interventions: Drug: nitroprusside; Drug: remifentanil

• Registration Number: NCT02001298
• Lead Sponsor: Jeju National University School of Medicine

Brief Summary

The purpose of this study is the comparison of the cardiovascular effects of remifentanil and nitroprusside for controlled hypotension

Detailed Description

Not available

Study Timeline

• Study Start: 2012-06
• Primary Completion: 2013-07
• Status Verified: 2013-11
• Study First Submitted: 2013-11-24
• Study First Submitted QC: 2013-12-03
• Last Update Submitted: 2013-12-03
• Study First Posted: 2013-12-04
• Last Update Posted: 2013-12-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patients who underwent endoscopic sinus surgery

Exclusion Criteria

• patient who took any drug to influence this study
• patient with cardiovascular disease, renal disease or liver disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
nitroprusside	nitroprusside	After induction of anesthesia, controlled hypotension was induced with continuous infusion of nitroprusside. Cardiac index, stroke volume index, and total peripheral resistance index were continuously measured using noninvasive cardiac output monitor (Cheetah NICOM, Cheetah Medical Inc, UK).
remifentanil	remifentanil	After induction of anesthesia, controlled hypotension was induced with continuous infusion of remifentanil. Cardiac index, stroke volume index, and total peripheral resistance index were continuously measured using noninvasive cardiac output monitor (Cheetah NICOM, Cheetah Medical Inc, UK).

Primary Outcome Measures

Name	Time	Method
Cardiac index	Cardiac index was continuously measured during controlled hypotension, an average of 90 min	Cardiac index was continuously measured during controlled hypotension using noninvasive cardiac output monitor. The average of cardiac index during controlled hypotension was compared with baseline value.

Secondary Outcome Measures

Name	Time	Method
Total peripheral resistance index	Total peripheral resistance index was continuously measured during controlled hypotension, an average of 90 min	Total peripheral resistance index was continuously measured during controlled hypotension using noninvasive cardiac output monitor. The average of total peripheral resistance index during controlled hypotension was compared with baseline value.

Trial Locations

Locations (1)

Jeju National University Hospital; 🇰🇷 Jeju-si, Jeju Special Self-Governing Province, Korea, Republic of