Sodium nitroprusside

Overview

Nitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.

Indication

For immediate reduction of blood pressure of patients in hypertensive crises, reduce bleeding during surgery, and for the treatment of acute congestive heart failure

Associated Conditions

Acute Heart Failure (AHF)
Hypertensive crisis
Intraoperative Blood Loss

Clinical Trials

Title	Posted	Study ID	Phase	Status	Sponsor
Early Neurovascular Adaptations in Aging Women	2024/07/25	NCT06520982	Early Phase 1	Recruiting	University of Missouri-Columbia
Role of Endothelial Function in SCI CVD Risk	2024/06/05	NCT06443151	N/A	Recruiting	Craig Hospital
Effects of an Antioxidant Supplement on Blood Vessel Health	2024/05/22	NCT06424756	Phase 2	Recruiting	University of Georgia
Estrogen and Microvascular Function	2023/09/21	NCT06043310	N/A	Active, not recruiting	Medical College of Wisconsin
Sex Differences in Sympathetic Vascular Reactivity at High Altitude	2022/09/01	NCT05525416	Not Applicable	Completed	University of Alberta
Effect of C21 on Forearm Blood Flow	2022/03/14	NCT05277922	Phase 1	Completed	Vicore Pharma AB
Hot Flashes and Neurovascular Function in Women	2022/01/18	NCT05193968	Not Applicable	Recruiting	Mayo Clinic
Sodium NItroPrusside Treatment in Acute Heart Failure	2021/08/30	NCT05027360	N/A	Completed	Niguarda Hospital
Sodium Nitroprusside in Early Course Schizophrenia	2021/08/02	NCT04986072	Phase 2	Terminated	Beth Israel Deaconess Medical Center
The Impact of Carbon Monoxide and Altitude on Vascular Function	2021/06/16	NCT04928183	Not Applicable	Completed	University of Alberta

FDA Drug Approvals

Approved Product	Manufacturer	NDC Code	Route	Strength	Effective Date
Sodium Nitroprusside	Somerset Therapeutics, LLC	70069-261	INTRAVENOUS	25 mg in 1 mL	12/14/2023
Sodium Nitroprusside	Dr.Reddy's Laboratories Inc.,	43598-587	INTRAVENOUS	50 mg in 2 mL	12/22/2016
Sodium Nitroprusside	Caplin Steriles Limited	65145-101	INTRAVENOUS	50 mg in 2 mL	11/29/2017
sodium nitroprusside in 0.9% sodium chloride	Slate Run Pharmaceuticals, LLC	70436-207	INTRAVENOUS	0.5 mg in 1 mL	11/15/2023
Sodium Nitroprusside	Hainan Poly Pharm. Co., Ltd.	14335-132	INTRAVENOUS	0.2 mg in 1 mL	12/31/2022
Sodium nitroprusside	Amneal Pharmaceuticals LLC	70121-1189	INTRAVENOUS	25 mg in 1 mL	12/27/2023
Sodium Nitroprusside	Hainan Poly Pharm. Co., Ltd.	14335-134	INTRAVENOUS	0.5 mg in 1 mL	12/31/2022
sodium nitroprusside	Nexus Pharmaceuticals Inc	14789-012	INTRAVENOUS	25 mg in 1 mL	5/9/2022
sodium nitroprusside in 0.9% sodium chloride	Slate Run Pharmaceuticals, LLC	70436-205	INTRAVENOUS	0.2 mg in 1 mL	11/15/2023
sodium nitroprusside in 0.9% sodium chloride	Slate Run Pharmaceuticals, LLC	70436-206	INTRAVENOUS	0.2 mg in 1 mL	11/15/2023

EMA Drug Approvals

Approved Product	Authorization Holder	Status	Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product	Manufacturer	Approval Number	Dosage Form	Strength	Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product	Company	Approval Number	Drug Type	Dosage Form	Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product	Registration No.	Company	Licence No.	Strength	Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product	ARTG ID	Sponsor	Registration Type	Status	Registration Date
SODIUM NITROPRUSSIDE BAXTER sodium nitroprusside 50 mg/2 mL concentrated injection vial	391482	Baxter Healthcare Pty Ltd	Medicine	A	5/16/2023
NITROPRUSSIDE-EMC sodium nitroprusside 50 mg/2 mL concentrated injection vial	328080	Emcure Pharmaceuticals Pty Ltd	Medicine	A	11/12/2020
DBL SODIUM NITROPRUSSIDE CONCENTRATED INJECTION sodium nitroprusside 25 mg/mL concentrated injection vial	177111	Pfizer Australia Pty Ltd	Medicine	A	6/15/2012
NITROPRUSSIDE TLB sodium nitroprusside 50mg/2mL concentrated injection vial	381451	Southern XP IP Pty Ltd	Medicine	A	11/14/2022
NITROPRUSSIDE RMB sodium nitroprusside 50mg/2mL concentrated injection vial	381452	Southern XP IP Pty Ltd	Medicine	A	11/14/2022
NITROPRUSSIDE SXP sodium nitroprusside 50mg/2mL concentrated injection vial	381450	Southern XP IP Pty Ltd	Medicine	A	11/14/2022
SODIUM NITROPRUSSIDE B&B sodium nitroprusside 50 mg/2 mL concentrated injection vial	317083	Micro Labs Pty Ltd	Medicine	A	2/25/2020
SODIUM NITROPRUSSIDE MICRO MEDICS sodium nitroprusside 50 mg/2 mL concentrated injection vial	317085	Micro Labs Pty Ltd	Medicine	A	2/25/2020
SODIUM NITROPRUSSIDE MLabs sodium nitroprusside 50 mg/2 mL concentrated injection vial	317066	Micro Labs Pty Ltd	Medicine	A	2/25/2020
SODIUM NITROPRUSSIDE MEDSURGE sodium nitroprusside 50 mg/2 mL concentrated injection vial	317084	Medsurge Pharma Pty Ltd	Medicine	A	2/25/2020

Health Canada Drug Approvals

Approved Product	Company	DIN	Dosage Form	Strength	Market Date
SODIUM NITROPRUSSIDE FOR INJECTION	Sterimax Inc	02450089	Solution - Intravenous	25 MG / ML	4/26/2021
CORA-BOSAN B43 - TAB	professional health products	02157713	Tablet - Oral	4 D	12/31/1996
NIPRIDE	hospira healthcare ulc	00336459	Powder For Solution - Intravenous	50 MG / VIAL	12/31/1975
NIPRIDE	Pfizer Canada Ulc	02361736	Solution - Intravenous	25 MG / ML	5/17/2011
SODIUM NITROPRUSSIDE FOR INJECTION	marcan pharmaceuticals inc	02479109	Solution - Intravenous	25 MG / ML	4/15/2019
SODIUM NITROPRUSSIDE FOR INJECTION	dr reddy's laboratories ltd	02507404	Solution - Intravenous	25 MG / ML	5/26/2021

CIMA AEMPS Drug Approvals

Approved Product	Company	Registration Number	Pharmaceutical Form	Prescription Type	Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product	Company	License Number	Dosage Form	Strength	Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product	Company	Registration Number	Dosage Form	Strength	Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name	MA Holder	MA Number	Pharmaceutical Form	Active Ingredient	Authorization Date
No UK EMC drug information found for this drug.

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