Early Neurovascular Adaptations in Aging Women

Early Phase 1

Recruiting

• Conditions: Aging; Women; Blood Flow; Sympathetic Nervous System
• Interventions: Drug: Norepinephrine; Drug: Isoproterenol; Drug: Acetylcholine; Drug: Nitroprusside; Drug: Estrogen

• Registration Number: NCT06520982
• Lead Sponsor: University of Missouri-Columbia

Brief Summary

Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-07-22
• Study First Submitted QC: 2024-07-22
• Study First Posted: 2024-07-25
• Status Verified: 2024-09
• Study Start: 2024-09-20
• Last Update Submitted: 2024-09-27
• Last Update Posted: 2024-10-01
• Primary Completion: 2027-06-30
• Study Completion: 2027-06-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 64

Inclusion Criteria

• Assigned female at birth (AFAB)
• 18-55 years of age

Exclusion Criteria

• Assigned male at birth (AMAB)
• Pregnancy, breastfeeding
• Body mass index ≥30 kg/m2
• Taking medications known to affect metabolic, autonomic, and/or respiratory function
• Oral hormonal contraception in last 6 month
• History of hormone replacement therapy
• History of hyster- or oophor-ectomy
• Current smoking/Nicotine use
• Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
• Chronic disease
• Blood pressure ≥140/90 mmHg
• Communication barriers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Women	Norepinephrine	Women will be 18-55 years of age
Women	Isoproterenol	Women will be 18-55 years of age
Women	Acetylcholine	Women will be 18-55 years of age
Women	Nitroprusside	Women will be 18-55 years of age
Women	Estrogen	Women will be 18-55 years of age

Primary Outcome Measures

Name	Time	Method
Magnitude of forearm blood flow	Change from baseline during infusion

Trial Locations

Locations (1)

University of Missouri-Columbia; 🇺🇸 Columbia, Missouri, United States