NCT06520982招募中早期 1 期
Early Neurovascular Adaptations in Aging Women
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 状态
- 招募中
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Magnitude of forearm blood flow
研究概览
简要总结
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Assigned female at birth (AFAB)
- •18-70 years of age
排除标准
- •Assigned male at birth (AMAB)
- •Pregnancy, breastfeeding
- •Body mass index ≥30 kg/m2
- •Taking medications known to affect metabolic, autonomic, and/or respiratory function
- •Oral hormonal contraception in last 6 month
- •History of hormone replacement therapy
- •History of hyster- or oophor-ectomy
- •Current smoking/Nicotine use
- •Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
- •Chronic disease
- •Blood pressure ≥140/90 mmHg
- •Communication barriers
研究组 & 干预措施
Women
Other
Women will be 18-70 years of age
干预措施: Norepinephrine (Drug)
Women
Other
Women will be 18-70 years of age
干预措施: Isoproterenol (Drug)
Women
Other
Women will be 18-70 years of age
干预措施: Acetylcholine (Drug)
Women
Other
Women will be 18-70 years of age
干预措施: Nitroprusside (Drug)
Women
Other
Women will be 18-70 years of age
干预措施: Estrogen (Drug)
结局指标
主要结局
Magnitude of forearm blood flow
时间窗: Change from baseline during infusion
次要结局
未报告次要终点
研究者
Jacqueline K Limberg, PhD
Associate Professor
University of Missouri-Columbia
研究点 (1)
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