Overview
A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.
Background
A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken down very rapidly by cholinesterases, but it is useful in some ophthalmological applications.
Indication
Used to obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy and other anterior segment surgery where rapid miosis may be required.
Associated Conditions
No associated conditions information available.
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2024/07/25 | Early Phase 1 | Recruiting | |||
2024/07/15 | Early Phase 1 | Not yet recruiting | |||
2024/06/12 | Not Applicable | Active, not recruiting | |||
2024/06/05 | N/A | Recruiting | |||
2023/09/21 | N/A | Active, not recruiting | |||
2023/07/14 | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | ||
2023/07/14 | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | ||
2022/12/16 | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | ||
2022/01/18 | Not Applicable | Recruiting | |||
2021/06/09 | Not Applicable | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| MIOCHOL-E INTRAOCULAR SOLUTION | SIN09252P | INJECTION | 20 mg/2 ml | 3/18/1997 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| MIOCHOL-E acetylcholine chloride 20mg/2mL powder for solution for intraocular irrigation | 118510 | Medicine | A | 8/31/2005 |