DeepMed Research

Norepinephrine

Generic Name: Norepinephrine

Brand Names: Levophed

Drug Type: Small Molecule

Chemical Formula: C_₈H_₁₁NO_₃

CAS Number: 51-41-2

Unique Ingredient Identifier: X4W3ENH1CV

Background: Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

Indication: Mainly used to treat patients in vasodilatory shock states such as septic shock and neurogenic shock and has shown a survival benefit over dopamine. Also used as a vasopressor medication for patients with critical hypotension.

Associated Conditions: Cardiac Arrest, Severe hypotension, Shock, Acute, severe Hypotension

Clinical Trials

Early Norepinephrine in Trauma Patients With Hemorrhagic Shock

Phase 1

Conditions: Trauma, Multiple

Interventions: Drug: Norepinephrine
Drug: Placebo

First Posted Date: 2025-05-18

Last Posted Date: 2025-05-18

Lead Sponsor: Visarat Palitnonkiat

Target Recruit Count: 40

Registration Number: NCT06977659

Locations: 🇹🇭
Faculty of Medicine Ramathibodi Hospital, Bangkok, Thailand
🇹🇭
Faculty of Medicine Siriraj Hospital, Bangkok, Thailand

Effect of Ephedrine vs. Norepinephrine on Prevention of Fetal Acidosis During Cesarean Section Under Spinal Anesthesia

Phase 4

Not yet recruiting

Conditions: Acidosis, Lactic
Hypotension After Spinal Anesthesia
Cesarean Delivery Affecting Newborn

Interventions: Drug: Ephedrine
Drug: Norepinephrine

First Posted Date: 2025-04-10

Last Posted Date: 2025-05-16

Lead Sponsor: mehmet özkılıç

Target Recruit Count: 100

Registration Number: NCT06921473

Ventriculo-arterial Coupling and Myocardial Work in Sepsis and Septic Shock

Not Applicable

Not yet recruiting

Conditions: Sepsis
Septic Shock

Interventions: Drug: Fluid therapy
Drug: Noradrenaline infusion

First Posted Date: 2025-03-03

Last Posted Date: 2025-03-03

Lead Sponsor: General and Teaching Hospital Celje

Target Recruit Count: 30

Registration Number: NCT06853574

Locations: 🇸🇮
General Hospital Celje, Celje, Slovenia

Postoperative Delirium After Intraoperative Ephedrine Versus Norepinephrine

Not yet recruiting

Conditions: Ephedrine
Norepinephrine
Postoperative Delirium (POD)

Interventions: Drug: Ephedrine
Drug: Norepinephrine

First Posted Date: 2025-02-25

Last Posted Date: 2025-02-25

Lead Sponsor: Riverside University Health System Medical Center

Target Recruit Count: 10000

Registration Number: NCT06844201

COMPARISON BETWEEN EFFICACY OF NOREPINEPHRINE AND PHENYLEPHRINE BOLUSES for PREVENTION OF SPINAL ANAESTHESIA INDUCED HYPOTENSION IN OBSTETRICAL PATIENTS UNDERGOING EMERGENCY CESAREAN SECTION-A Double Blind Randomized Controlled Trial

Not Applicable

Recruiting

Conditions: Spinal Anesthesia Induced Hypotension

Interventions: Drug: Phenylephrine bolus
Drug: Norepinephrine Bolus

First Posted Date: 2025-02-20

Last Posted Date: 2025-02-20

Lead Sponsor: Dow University of Health Sciences

Target Recruit Count: 124

Registration Number: NCT06836986

Locations: 🇵🇰
Dr Ruth km pfau civil hospital karachi Dow University of health sciences, department of anesthesiology, Karachi, Sindh, Pakistan

The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery

Phase 4

Recruiting

Conditions: Anesthesia
Surgery With General Anesthesia
Noncardiac Surgery
Hypotension During Surgery
Acute Kidney Injury (AKI)
Myocardial Injury After Noncardiac Surgery (MINS)
Vasopressor

Interventions: Drug: Norepinephrine
Drug: Phenylephrine

First Posted Date: 2025-01-31

Last Posted Date: 2025-04-15

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 18000

Registration Number: NCT06802224

Locations: 🇺🇸
University of California, San Francisco, San Francisco, California, United States
🇺🇸
University of Michigan, Ann Arbor, Michigan, United States

Evaluation of Post-Induction Hypotension Treatment with PRAM Method

Active, not recruiting

Conditions: Hypotension on Induction

Interventions: Drug: Ephedrine
Drug: Noradrenalin

First Posted Date: 2025-01-22

Last Posted Date: 2025-03-05

Lead Sponsor: Ankara City Hospital Bilkent

Target Recruit Count: 100

Registration Number: NCT06787404

Locations: 🇹🇷
Ankara Bilkent Şehir Hastanesi, Ankara, Turkey

Dysfunctional Renin-Angiotensin System in Septic Shock

Phase 4

Not yet recruiting

Conditions: Septic Shock

Interventions: Drug: Angiotensin II
Drug: Norepinephrine

First Posted Date: 2024-12-24

Last Posted Date: 2025-03-25

Lead Sponsor: Wake Forest University Health Sciences

Target Recruit Count: 78

Registration Number: NCT06746753

Locations: 🇺🇸
Atrium Health Wake Forest Baptist, Winston-Salem, North Carolina, United States

Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）

Not Applicable

Recruiting

Conditions: Tumor
Stroke

Interventions: Drug: Norepinephrine or phenylephrine

First Posted Date: 2024-12-02

Last Posted Date: 2024-12-02

Lead Sponsor: Zhejiang Cancer Hospital

Target Recruit Count: 214

Registration Number: NCT06711432

Locations: 🇨🇳
Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China

Reducing Cardiac-surgery Associated Acute Kidney Injury Occurence by Administering Angiotensin II

Phase 3

Not yet recruiting

Conditions: Cardiac Surgery
Vasoplegia

Interventions: Drug: Angiotensin II
Drug: Noradrenalin

First Posted Date: 2024-09-26

Last Posted Date: 2024-09-26

Lead Sponsor: Universität Münster

Target Recruit Count: 1022

Registration Number: NCT06615102

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