Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Right ventricle 2D strain
研究概览
简要总结
Acute respiratory distress syndrome (ARDS) and mechanical ventilation can lead to right ventricular dysfunction and ultimately right ventricular failure by increasing pulmonary vascular resistances and pressure load. This can be prevented by modifying ventilator settings, using vasopressors or inotropes or even by prone positionning.But to do so, right ventricular dysfonction has to be detected. Echocardiography has emerged as a first line tool to diagnose right heart failure. Recently, strain analysis showed promising results to detect early right ventricle abnormalities in other settings such as pulmonary hypertension or scleroderma. We therefore decided to determine whether 2D strain could help detect early right ventricular dysfunction in ARDS.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Need for mechanical ventilation
- •ARDS criteria met: Respiratory failure not fully explained by cardiac failure, Pao2/FiO2<200, bilateral opacities on Chest imaging, all symptoms appeared within 1 week
排除标准
- •Predictable duration of mechanical ventilation shorter than 48 hours
- •Contraindication to transesophageal echocardiography
- •Inclusion Criteria:
- •Need for mechanical ventilation
- •ALI criteria met: Respiratory failure not fully explained by cardiac failure, Pao2/FiO2<300, bilateral opacities on Chest imaging, all symptoms appeared within 1 week
- •Exclusion Criteria:
- •Predictable duration of mechanical ventilation shorter than 48 hours
- •Control Group:
- •Inclusion Criteria:
- •Need for mechanical ventilation for a non-respiratory cause
- •Exclusion Criteria:
- •Need for FiO2>30%
- •Known cardiac abnormalities
- •Cardiac drugs intake during last 24 hours
结局指标
主要结局
Right ventricle 2D strain
时间窗: Duration of mechanical ventilation
We will assess whether 2D strain can detect a right ventricular dysfunction as compared to standard echocardiographic parameters
次要结局
- Mean right ventricle strain under ventilated patients(at inclusion)
- Reproducibility between transthoracic and transesophageal strain measures(Time of mechanical ventilation)
- NT pro BNP and pre pro endothelin plasma level(At inclusion in ARDS patients)