Effects of Aerobic and Resistance Training on Abdominal Fat Loss

Not Applicable

Terminated

• Conditions: Obesity, Abdominal

• Registration Number: NCT03700827
• Lead Sponsor: Southern Illinois University Edwardsville

Brief Summary

Study the effects of different exercise modes on total and regional adiposity variation in subcutaneous and visceral adipose tissue (VAT and SAT). The investigators hypothesize that total abdominal will improve for all the exercise groups compared to the control group. When comparing intervention groups: 1) no differences on the degree of improvement in total abdominal fat depots (VAT and SAT) 2) different degree of change when comparing specific sections at VAT and SAT are expected.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-10-01
• Study First Submitted: 2018-09-05
• Study First Submitted QC: 2018-10-05
• Study First Posted: 2018-10-09
• Primary Completion: 2020-04-01
• Study Completion: 2020-05-01
• Status Verified: 2021-03
• Last Update Submitted: 2021-09-27
• Last Update Posted: 2021-10-04

Recruitment & Eligibility

• Status: TERMINATED
• Sex: Female
• Target Recruitment: 18

Inclusion Criteria

• 30 - 39.9 kg/m2 BMI
• White/Caucasian
• Female
• Sedentary

Exclusion Criteria

• Known cardiovascular, pulmonary, metabolic disease
• Pregnant females
• Any excluded criteria with MRI scans (i.e. certain metal implants, recent tattoos)
• Diabetic
• Hypertension
• Cigarette smoking
• MRI related contraindications (metal, no removable devices, etc.)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Changes in Visceral Abdominal Tissue (VAT)	2 assessment periods: at baseline and week 4	Changes in VAT will be measured using Magnetic Resonance Imaging

Secondary Outcome Measures

Name	Time	Method
Changes in relative body fat (%BF)	2 assessment periods: at baseline and week 4	Changes in body composition (relative body fat, lean body mass and fat mass) will be measured using dual-energy x-ray absorptiometry
Changes in Muscular Strength	2 assessment periods: at baseline and week 4	Changes in muscular strength will be assessed by one-repetition maximum test on leg press and bench press
Changes in Cardiorespiratory Function	2 assessment periods: at baseline and week 4	Changes in cardiorespiratory will measured on a treadmill with a metabolic cart
Changes in Lipid profile (TG, Total Cholesterol, HDL2 HDL3, LDL)	2 assessment periods: at baseline and week 4	Samples will be processed to obtain serum and plasma, and stored at -80°c until analysis
Changes in concentration of Troponin	2 assessment periods: at baseline and week 4	Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in Subcutaneous Abdominal Tissue (SAT)	2 assessment periods: at baseline and week 4	Changes in SAT will be measured using Magnetic Resonance Imaging
Changes in relative lean body mass (kg)	2 assessment periods: at baseline and week 4	Changes in lean body mass will be measured using dual-energy x-ray absorptiometry
Changes in concentration of IL-6	2 assessment periods: at baseline and week 4	Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of IL-10	2 assessment periods: at baseline and week 4	Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of Fibrinogen	2 assessment periods: at baseline and week 4	Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in fat mass (kg)	2 assessment periods: at baseline and week 4	Changes in fat mass will be measured using dual-energy x-ray absorptiometry
Changes in concentration of C-reactive protein (CRP)	2 assessment periods: at baseline and week 4	Will be performed using a Luminex MAGPIX System with xPONENT 4.2
Changes in concentration of TNF-alpha	2 assessment periods: at baseline and week 4	Will be performed using a Luminex MAGPIX System with xPONENT 4.2

Trial Locations

Locations (1)

Southern Illinois University of Edwardsville; 🇺🇸 Edwardsville, Illinois, United States