Gallbladder Functions & Serum Cholecystokinin Levels in Pregnant Women Diagnosed With Hyperemesis Gravidarum
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 325
- 试验地点
- 1
- 主要终点
- Blood Cholecystokinin (CCK) Levels
研究概览
简要总结
This study evaluates the gallbladder functions and serum cholecystokinin levels in pregnant women diagnosed with hyperemesis gravidarum. Half of the participants are healthy pregnant women and half of the participants are pregnant women diagnosed with hyperemesis gravidarum. Two groups will be compared by means of gallbladder functions and serum cholecystokinin levels.
详细描述
Previously gallbladder functions have been observed in human with gallbladder disease. However it has never been evaluated whether there is any difference in gallbladder functions between healthy pregnant women and pregnant women diagnosed with hyperemesis gravidarum. Moreover correlation between hyperemesis gravidarum symptom scores and gallbladder functions has never been assessed. There is also few data comparing serum cholecystokinin levels between healthy pregnant women and those diagnosed with hyperemesis gravidarum. The investigators will measure serum cholecystokinin levels after a fatty meal (100 g chocolate) and compare two groups. In this study the investigators would like to evaluate gallbladder functions and serum cholecystokinin levels in women with hyperemesis gravidarum and compare these with healthy subjects.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 40 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •gestation week between 6 and 14 weeks,
- •singleton pregnancy with a live embryo,
- •healthy women without any medical disorders,
- •Exclusion Criteria
- •any systemic disease,
- •gallbladder disease
- •any psychological disorder that can cause vomiting,
- •multiple gestation
排除标准
- 未提供
结局指标
主要结局
Blood Cholecystokinin (CCK) Levels
时间窗: Fasting (baseline) and postprandial (15 minutes after the test meal) CCK level
a gut hormone released, its level can be measured in blood as fasting level and postprandial
Gallbladder (GB) Ejection Fraction
时间窗: The fasting and postprandial 45th minute
GB ejection fraction measures how much bile gallbladder releases at one time, expressed as percentage
Gallbladder (GB) Volume
时间窗: fasting and postprandial 45th minute
volume of GB measured with abdominal ultrasound at fasting and postprandial
Gallbladder (GB) Wall Thickness
时间窗: fasting and postprandial 45th minute
GB wall thickening measured with abdominal ultrasound at fasting and postprandial
次要结局
未报告次要终点
研究者
Müge Keskin
Principal investigator
Ufuk University
